Results 51 to 60 of about 2,217 (170)

Synergy of piracetam and aminalon in the cerebroprotective effect of olatropyl.

Medičnì Perspektivi, 2018
Optimization of pharmacotherapy of neurological and psychosomatic diseases led to the creation of com­bined medicines containing two or more components with different mechanisms of action, differently affecting the pathogenesis and clinical ...
V. I. Mamchur, S. N. Dronov
doaj   +1 more source

Molecular Insights Into Repurposed Drug Interactions With HDAC11 for Advancing Epigenetic Therapeutics in Cancer and Neurodegenerative Diseases

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Histone deacetylase 11 (HDAC11) is a member of the HDAC family that plays a crucial role in epigenetic regulation, influencing key cellular processes like transcription, differentiation, and proliferation. Abnormal expressions and functions of HDAC11 have been described in various diseases, including neurodegenerative diseases and cancer, highlighting ...
Yinsheng Yang, Khalida Ahmed Mohammed Ahmed, Khuzin Dinislam, Pratibha Prasad, Akhtar Atiya, Sohini Basu Roy   +5 more
wiley   +1 more source

Simply crushed zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice

eLife
Neurodegenerative diseases are age-related disorders characterized by the cerebral accumulation of amyloidogenic proteins, and cellular senescence underlies their pathogenesis. Thus, it is necessary for preventing these diseases to remove toxic proteins,
Tomohiro Umeda, Ayumi Sakai, Rumi Uekado, Keiko Shigemori, Ryota Nakajima, Kei Yamana, Takami Tomiyama   +6 more
doaj   +1 more source

Lawsonia Inermis Markedly Improves Cognitive Functions in Animal Models and Modulate Oxidative Stress Markers in the Brain

Medicina, 2019
Background and Objective: Medicinal plants represent an important source of alternative medicine for the management of various diseases. The present study was undertaken to assess the potential of Lawsonia inermis ethanol (Li.Et) and chloroform (Li.Chf ...
Numra Tariq Mir, Uzma Saleem, Fareeha Anwar, Bashir Ahmad, Izhar Ullah, Sundas Hira, Tariq Ismail, Tahir Ali, Muhammad Ayaz   +8 more
doaj   +1 more source

A Novel Functional Ingredient Derived From a Mixture of Mulberry (Morus alba L.) Leaves and Butterfly Pea (Clitoria ternatea L.) Flowers Enhances Rapid Eye Movement Sleep, Cognitive Function, and Anxiolytic Behavior via GABAA Receptor‐Dependent Mechanism in Rats

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
The neuropharmacological benefits for sleep quality and mental health from the extracts of Morus alba L. leaves (MA) and Clitoria ternatea L. flowers (CT) have been revealed previously. However, due to synergistic interactions of polyherbal ingredients, the positive effects of MA mixed with CT are still controversial. Preliminary outcomes from in vitro
Jakkrit Nukitram, Aonvara Kanjanavattana, Panlekha Rungruang, Nattaporn Yotyatthai, Pannita Kaewudom, Pichayapa Promkasikorn, Patharakan Kaowsuwan, Nobuhiro Zaima, Dania Cheaha, Wipawee Thukhammee, Jintanaporn Wattanathorn, Josep Rubert   +11 more
wiley   +1 more source

Advances in Pharmacological Insights of Borago officinalis: A Comprehensive Review

Biological Diversity, Volume 2, Issue 4, Page 193-205, December 2025.
ABSTRACT Recent growth in phytotherapy and product‐based drug development has increased interest in this plant because of its broad pharmacological activity. This review aims to examine the pharmacological activities, mechanisms, and potential applications of Borago officinalis, focusing on its primary bioactive constituents and therapeutic ...
Zahra Sufwan, Javed Akhtar Ansari, Farogh Ahsan   +2 more
wiley   +1 more source

Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

ChemistryOpen, Volume 14, Issue 12, December 2025.
Structure‐based virtual screening of PubChem compounds identifies two novel epalrestat and ranirestat‐like inhibitors with improved affinity and pharmacokinetic profiles targeting aldose reductase. Molecular docking, ADMET filtering, and 500‐ns molecular dynamics simulations confirm the stability and interaction specificity of the candidates ...
Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Anas Shamsi   +3 more
wiley   +1 more source

Pharmaceutical Neuroenhancement in the Quest for Worth at Work

Sociological Inquiry, Volume 95, Issue 4, Page 834-850, November 2025.
This article examines the use of psychoactive substances for cognitive enhancement in the context of work. By drawing upon existing qualitative research and sociological theories on meaningful work, valuation, and human agency, I explore cultural and institutional processes encouraging individuals to engage in such practices and argue that ...
Sigita Doblytė
wiley   +1 more source

Sports Supplement Analysis Survey for the Prevalence of WADA Prohibited Substances in the Australian Online Marketplace

Drug Testing and Analysis, Volume 17, Issue 10, Page 1857-1864, October 2025.
A survey of 200 sports supplements purchased online in Australia and analysed for WADA Prohibited Substances. Athlete education regarding the use of sports supplements remains a high priority as 35% of the products contained WADA Prohibited Substances. ABSTRACT Sports supplements are used extensively by people involved in competitive sports. However, a
Louise Barker, Adam Cawley, Naomi Speers, Kerry Knowler, Karina Chilman   +4 more
wiley   +1 more source

Mnestic functions restoration due to chronic brain ischemia pathogenetically oriented pharmacocorrection as a condition to enhance cerebral resistance

Journal of Education, Health and Sport
The purpose of the study was to investigate the efficacy of separate and combined administration of pentoxifylline, memantine and xavron in the pharmacological correction of cognitive impairment in rats under conditions of experimental chronic brain ...
O. Myronov
doaj   +1 more source