Results 61 to 70 of about 2,327 (198)

Molecular Insights Into Repurposed Drug Interactions With HDAC11 for Advancing Epigenetic Therapeutics in Cancer and Neurodegenerative Diseases

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Histone deacetylase 11 (HDAC11) is a member of the HDAC family that plays a crucial role in epigenetic regulation, influencing key cellular processes like transcription, differentiation, and proliferation. Abnormal expressions and functions of HDAC11 have been described in various diseases, including neurodegenerative diseases and cancer, highlighting ...
Yinsheng Yang, Khalida Ahmed Mohammed Ahmed, Khuzin Dinislam, Pratibha Prasad, Akhtar Atiya, Sohini Basu Roy   +5 more
wiley   +1 more source

A Novel Functional Ingredient Derived From a Mixture of Mulberry (Morus alba L.) Leaves and Butterfly Pea (Clitoria ternatea L.) Flowers Enhances Rapid Eye Movement Sleep, Cognitive Function, and Anxiolytic Behavior via GABAA Receptor‐Dependent Mechanism in Rats

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
The neuropharmacological benefits for sleep quality and mental health from the extracts of Morus alba L. leaves (MA) and Clitoria ternatea L. flowers (CT) have been revealed previously. However, due to synergistic interactions of polyherbal ingredients, the positive effects of MA mixed with CT are still controversial. Preliminary outcomes from in vitro
Jakkrit Nukitram, Aonvara Kanjanavattana, Panlekha Rungruang, Nattaporn Yotyatthai, Pannita Kaewudom, Pichayapa Promkasikorn, Patharakan Kaowsuwan, Nobuhiro Zaima, Dania Cheaha, Wipawee Thukhammee, Jintanaporn Wattanathorn, Josep Rubert   +11 more
wiley   +1 more source

Lawsonia Inermis Markedly Improves Cognitive Functions in Animal Models and Modulate Oxidative Stress Markers in the Brain

Medicina, 2019
Background and Objective: Medicinal plants represent an important source of alternative medicine for the management of various diseases. The present study was undertaken to assess the potential of Lawsonia inermis ethanol (Li.Et) and chloroform (Li.Chf ...
Numra Tariq Mir, Uzma Saleem, Fareeha Anwar, Bashir Ahmad, Izhar Ullah, Sundas Hira, Tariq Ismail, Tahir Ali, Muhammad Ayaz   +8 more
doaj   +1 more source

Advances in Pharmacological Insights of Borago officinalis: A Comprehensive Review

Biological Diversity, Volume 2, Issue 4, Page 193-205, December 2025.
ABSTRACT Recent growth in phytotherapy and product‐based drug development has increased interest in this plant because of its broad pharmacological activity. This review aims to examine the pharmacological activities, mechanisms, and potential applications of Borago officinalis, focusing on its primary bioactive constituents and therapeutic ...
Zahra Sufwan, Javed Akhtar Ansari, Farogh Ahsan   +2 more
wiley   +1 more source

Zingiber officinale   : Evaluation of its Nootropic effect in mice

, 2006
Dementia is one of the age-related mental problems, and a characteristic symptom of Alzheimer's disease. Nootropic agents and cholinesterase inhibitors like donepezil® are clinically used in situations where there is organic disorder in learning ...
Milind Parle, Hanumanthachar Joshi
core   +1 more source

Simply crushed zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice

eLife
Neurodegenerative diseases are age-related disorders characterized by the cerebral accumulation of amyloidogenic proteins, and cellular senescence underlies their pathogenesis. Thus, it is necessary for preventing these diseases to remove toxic proteins,
Tomohiro Umeda, Ayumi Sakai, Rumi Uekado, Keiko Shigemori, Ryota Nakajima, Kei Yamana, Takami Tomiyama   +6 more
doaj   +1 more source

Behavioral and biomarker assessment of flavonols as multifunctional neuroprotective nootropic agents

Future Medicinal Chemistry
This study aimed to evaluate the behavioral and biochemical effects of synthesized flavonols (1-10) as potential nootropic, antidepressant, and antistress agents.Behavioral assessments were conducted using animal models to evaluate memory impairment, depression, and stress responses.
Ehsan Ullah Mughal, Nafeesa Naeem, Mohammad Raish, Bushra Shakoor, Amina Sadiq, Syed Wadood Ali Shah, Muhammad Naeem Ahmed, Muhammad Zahoor, Ishtiaq Ahmed, Mehreen Ghias   +9 more
openaire   +3 more sources

Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

ChemistryOpen, Volume 14, Issue 12, December 2025.
Structure‐based virtual screening of PubChem compounds identifies two novel epalrestat and ranirestat‐like inhibitors with improved affinity and pharmacokinetic profiles targeting aldose reductase. Molecular docking, ADMET filtering, and 500‐ns molecular dynamics simulations confirm the stability and interaction specificity of the candidates ...
Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Anas Shamsi   +3 more
wiley   +1 more source

Експериментальне обґрунтування доцільності сумісного застосування пірацетаму і метформіну для фармакологічної корекції когнітивних розладів за умов тривалої гіперглікемії [PDF]

, 2020
Стратегически важными звеньями развития когнитивного дефицита при диабетической энцефалопатии считают хроническую гипергликемию, инсулинорезистентность, эндотелиальную дисфункцию и нарушение целостности гематоэнцефалического барьера.
Лєвих, А.Е., Дронов, С.М., Мамчур, В.Й., Твердохліб, І.В., Бондаренко, Н.С., Жилюк, В.І.   +5 more
core  

Pharmaceutical Neuroenhancement in the Quest for Worth at Work

Sociological Inquiry, Volume 95, Issue 4, Page 834-850, November 2025.
This article examines the use of psychoactive substances for cognitive enhancement in the context of work. By drawing upon existing qualitative research and sociological theories on meaningful work, valuation, and human agency, I explore cultural and institutional processes encouraging individuals to engage in such practices and argue that ...
Sigita Doblytė
wiley   +1 more source