Results 81 to 90 of about 3,775 (250)
Pharmacokinetic properties of an innovative nootropic agent based on a derivative of 3,7-diazabicyclo[3.3.1]nonane [PDF]
, 2020 G.E. Brkich +5 more
openalex +1 more source
Moral enhancement and cheapened achievement: Psychedelics, virtual reality and AI
Bioethics, Volume 39, Issue 3, Page 276-287, March 2025.Abstract A prominent critique of cognitive or athletic enhancement claims that certain performance‐improving drugs or technologies may ‘cheapen’ resulting achievements. Considerably less attention has been paid to the impact of enhancement on the value of moral achievements.
Emma C. Gordon +3 more
wiley +1 more source
Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice [PDF]
, 2017 Hericium erinaceus (Bull.) Pers. is a medicinal mushroom capable of inducing a large number of modulatory effects on human physiology ranging from the strengthening of the immune system to the improvement of cognitive functions.
Botta L +10 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 3, March 2025.AE activates the AMPK/PGC‐1α/SIRT3 pathway. Increased expression of SIRT3 in mitochondria promotes mitophagy and regulates the function of mitochondrial proteins. Consequently, the mitochondrial membrane potential, GSH, ROS, and Ca2+ levels gradually recover, alleviating the pathological manifestations of ad.
Yulu Wang +5 more
wiley +1 more source
Promoting Successful Cognitive Aging: A Comprehensive Review [PDF]
, 2014 Promoting successful cognitive aging is a topic of major importance to individuals and the field of public health. This review presents a coherent framework not only for evaluating factors, protective activities, and enhancing agents that have already ...
Daffner, Kirk R.
core +1 more source
BioFactors, Volume 51, Issue 1, January/February 2025.Modulation of thiol redox signaling by thiamine disulfide derivatives depends on the relative efficiency of glutathione and thioredoxin systems. Abstract Thiamine (vitamin B1), under the proper conditions, is able to reversibly open the thiazole ring, forming a thiol‐bearing molecule that can be further oxidized to the corresponding disulfide.
Alessandra Folda +4 more
wiley +1 more source
Scientifica, Volume 2025, Issue 1, 2025.Aging increases the risk of neurodegenerative diseases such as Parkinson’s and Alzheimer’s (PD and AD) which are potentially linked to increased oxidative stress and inflammation. Paracetamol (APAP) is known for its antioxidant and anti‐inflammatory properties; however, its potential neuroprotective effects against age‐related oxidative stress and ...
Chuchard Punsawad +5 more
wiley +1 more source
A practical application of text mining to literature on cognitive rehabilitation and enhancement through neurostimulation [PDF]
, 2014 The exponential growth in publications represents a major challenge for researchers. Many scientific domains, including neuroscience, are not yet fully engaged in exploiting large bodies of publications.
Balan, Puiu F. +2 more
core +1 more source
The tricyclic antidepressant desipramine inhibited the neurotoxic, kainate-induced [Ca] increases in CA1 pyramidal cells in acute hippocampal slices. [PDF]
, 2014 Kainate (KA), used for modelling neurodegenerative diseases, evokes excitotoxicity. However, the precise mechanism of KA-evoked [Ca2+]i increase is unexplored, especially in acute brain slice preparations.
Kiss, János +7 more
core +1 more source
Nanoparticle transport across the blood brain barrier [PDF]
, 2016 : While the role of the blood-brain barrier (BBB) is increasingly recognized in the (development of treatments targeting neurodegenerative disorders, to date, few strategies exist that enable drug delivery of non-BBB crossing molecules directly to their ...
BELLETTI, Daniela +6 more
core +1 more source