Results 221 to 230 of about 191,218 (299)

Clinical Parameters Associated with Achieving Negative Fluid Balance in Critically Ill Patients: A Retrospective Cohort Study. [PDF]

J Clin Med
Stavi D, Gal Oz A, Adi N, Dayan RR, Angel Y, Nevo A, Khoury N, Moshkovits I, Lichter Y, Wald R, Goder N.   +10 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Vasoactivity of Rac GTPase, Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibitory Effects in Vascular and Prostate Smooth Muscle Contraction. [PDF]

Pharmacol Res Perspect
Liu G, Hu S, Tamalunas A, Kale O, Xu Y, Stief CG, Hennenberg M.   +6 more
europepmc   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Experimental Investigation of Fentanyl Analgesic Potency and Its Relationship with Endogenous Adrenaline Levels in Rats. [PDF]

J Pain Res
Ates I, Isik B, Sezgin ET, Altuner D, Coban TA, Suleyman H.   +5 more
europepmc   +1 more source

Dissociating role of Bassoon in glutamatergic and dopaminergic neurons in alcohol‐related behaviour and affective state in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Alcohol abuse and affective disorders are severe comorbid psychiatric diseases characterized by impaired brain synaptic transmission. The role of presynaptic scaffolding proteins coordinating presynaptic plasticity and neurotransmitter release, such as Bassoon (Bsn), in the pathogenesis of these disorders remains elusive.
Liubov S. Kalinichenko, Mona Krenbauer, Janosh Isert, Marlon Kamlah, Thorben Tanzer, Hannes Rödel, Tobias Müller, Anil Annamneedi, Enes Yağız Akdaş, Volker Eulenburg, Bernd Lenz, Eckart D. Gundelfinger, Johannes Kornhuber, Anna Fejtova, Christian P. Müller   +14 more
wiley   +1 more source

Intraoperative Hypotension and Vasoactive Treatment: An International Survey of Anaesthesiologists. [PDF]

Acta Anaesthesiol Scand
Bækgaard ES, Vester-Andersen M, Crone V, Møller MH, Yamanaka S, Palmarsdottir R, Uusalo P, Haidl F, Rådestad M, van der Sloot K, Corona A, Johnström A, Nørskov AK, Karlsen APH, Faustad BI, Sørensen CB, Spies F, Krogh HB, El-Hallak H, Mistry JM, Mønnich JK, Olesen KG, Madsen KPD, Voogd KL, Reich LM, Kolstrup LA, Juhl-Olsen P, Körner LK, Sigurdsson MI, Jensen-Holm MB, Slavensky JA, Toft MH, Jørgensen ML, Andersen M, Jensen MSH, Saei M, Hedetoft M, Hansen PM, Hansen RT, Lundsgaard RS, Krarup SMI, Wiberg S, Laustrup T, Brizzi G, Kreutziger J, Onyemuchara I, Adeniji A, Colville T, Keitley JA, Khan M, Millar M, Lennie I, Kelly K, Brooker V, Roberts J, Lipton G, Keohone J, Chebbout R, Bond O, Milligan W, O'Brien C, Wright E, Linton F, Towell C, Shuttleworth J, Norton J, Butler D, Frankland S, Screech F, Charig L, Walsh S, Davies R, Jones E, Dalmonte E, Evans M, Krag M.   +75 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Refractory Hypotension and Delayed Respiratory Failure in Amlodipine Toxicity: A Multimodal Management Approach. [PDF]

Cureus
Haq M, Iloanugo C, Momoh R.
europepmc   +1 more source

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Noise pollution, particularly by aircraft, is a significant risk factor for cardiovascular disease. Aircraft noise activates stress response pathways in the brain, via the amygdala, the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis.
Ivana Kuntić, Marin Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Hans‐Georg Buchholz, Nicole Bausbacher, Simon Lange, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Axel Methner, Sebastian Steven, Huige Li, Mathias Schreckenberger, Dilja Krueger‐Burg, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber   +25 more
wiley   +1 more source