Results 231 to 240 of about 147,087 (295)

Vasoactive drug use in children with community acquired septic shock in Australia and New Zealand. [PDF]

Lancet Reg Health West Pac
Long E, Hearps S, Williams A, Gelbart B, Butt W, Rozen T, McNab S, Borland ML, Erickson S, Jani S, Festa M, Tan E, Phillips N, Raman S, Kochar A, Ganu S, Craig S, Lithgow A, Rao A, Whyte E, Dalziel SR, George S, Balamuth F, Weiss SL, Kuppermann N, Babl FE, Paediatric Research in Emergency Departments International Collaborative (PREDICT) network.   +26 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Validating molecular target-enriched fMRI for disentangling drug effects on dopamine. [PDF]

Imaging Neurosci (Camb)
van den Bosch R, Cools R.
europepmc   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Vasopressor Requirements after Initiation of Venovenous Extracorporeal Membrane Oxygenation in Patients with Severe Respiratory Failure. [PDF]

Ann Intensive Care
Nagler B, Buchtele N, Schellongowski P, Robak O, Hermann A, Staudinger T.   +5 more
europepmc   +1 more source

Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5‐HT2A receptor

British Journal of Pharmacology, EarlyView.
A pharmacological profiling of 58 synthetic stimulants of various classes at dopamine, norepinephrine, and serotonin transporters and the 5‐HT2A receptor, most showing distinct class‐dependent profiles, with some indicating a high abuse potential. Background and Purpose New psychoactive substances (NPSs) often emerge on the illicit drug market with ...
Darta Stalberga, Robert Kronstrand, Bianca Schranz, Nick van Zijl, Sebastian Karlman, Soma Aref, Tobias Rautio, Svante Vikingsson, Mattias Persson, Henrik Green   +9 more
wiley   +1 more source

A Bioactive Benzyl Terpene from <i>Acridocarpus smeathmannii</i> Inhibits Human Prostate Smooth Muscle Contractility. [PDF]

Molecules
Kale OE, Huber C, Schuldeis D, Tamalunas A, Hennenberg M, Eisenreich W.   +5 more
europepmc   +1 more source

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, EarlyView.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

Noradrenaline-trajectory phenotypes in septic shock: derivation and external validation in two independent cohorts. [PDF]

Intensive Care Med Exp
Yonatan G, Cohen A, Stein D, Levi O, Cohen D, Klein J, Taube HS, Vine J, Glebov M, Lazebnik T, Saban M, Haviv Y, Segal E.   +12 more
europepmc   +1 more source

Effect of Medication Intake on Dental Implant‐Related Outcomes—A Scoping Review

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objective The objective of this scoping review was to evaluate the effect of systemic medications on dental implant outcomes in medically compromised patients. Material and Methods Electronic and manual searches were conducted for this scoping review.
Alberto Monje, Maria Costanza Soldini, Emilio Couso‐Queiruga, Álvaro Babiano, Vivianne Chappuis   +4 more
wiley   +1 more source