Results 101 to 110 of about 41,607 (263)

Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy

Experimental Physiology, EarlyView.
Abstract Attenuation of sympathetic vasoconstriction during exercise (functional sympatholysis) contributes to skeletal muscle oxygen delivery–utilization matching. However, the extent to which muscle contractions impact noradrenergic regulation of interstitial oxygen pressures (PO2is${P_{{{\mathrm{O}}_2}}}_{{\mathrm{is}}}$; the driving force for blood–
Edward T. N. Calvo, Jacob M. Pontorno, Benjamin Zeidler, Taciane M. M. Pejon, Michael D. Belbis, Scott K. Ferguson, Craig J. Goergen, Timothy P. Gavin, Bruno T. Roseguini, Igor A. Fernandes, Daniel M. Hirai   +10 more
wiley   +1 more source

The skeletal muscle–adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management

Experimental Physiology, EarlyView.
Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su, Na Liu, Yang Liu, Yiqun Sun, Yike Jiao   +4 more
wiley   +1 more source

Recent optical approaches for anatomical and functional dissection of neuron–astrocyte circuitry

The Journal of Physiology, EarlyView.
Abstract figure legend This review summarises novel optical approaches to deciphering structural and functional wiring diagrams of neuron–astrocyte circuits in the brain. There are three groups: the anatomical proximity assay, transsynaptic viral tracing and the functional connection assay. The FRET‐based neuron–astrocyte proximity assay allows mapping
Yoshiki Hatashita, Takafumi Inoue
wiley   +1 more source

Noradrenergic control of bone marrow and thymus by AgRP neurons is impaired in experimental multiple sclerosis

Cell Reports
Summary: Maturation of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow (BM) and of T lymphocytes in the thymus occurs within stromal regions innervated by noradrenergic fibers of the sympathetic nervous system (SNS).
Tiziana Vigo, Maria C. Mariani, Caterina Bason, Giovanni Ferrara, Eleonora Cornacchia, Simona Francia, Alberto Potenzieri, Erika Ricci, Giorgio Grasselli, Gabriele Zoppoli, Gabriella Cirmena, Lorenzo Ferrando, Claudio Procaccini, Claudia Russo, Tiziana Altosole, Elena Cerutti, Giovanna Capodivento, Marta Bottero, Luca Liberale, Marco Scotto, Alice Laroni, Matilde Inglese, Sebastian Sulis Sato, Jonatas Catarino, Diego Centonze, Giuseppe Matarese, Fabio Benfenati, Tamas L. Horvath, Nicole Kerlero de Rosbo, Antonio Uccelli   +29 more
doaj   +1 more source

Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis

The Journal of Physiology, EarlyView.
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation

eLife
When retrieved, seemingly stable memories can become sensitive to significant events, such as acute stress. The mechanisms underlying these memory dynamics remain poorly understood.
Hendrik Heinbockel, Gregor Leicht, Anthony D Wagner, Lars Schwabe   +3 more
doaj   +1 more source

Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli [PDF]

, 1987
ED Abercrombie, BL Jacobs
openalex   +1 more source

Differential working memory changes following methylphenidate in medication‐naive and medication‐experienced adults with ADHD

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Aim The long‐term impact of pharmacological treatment on cognitive function in adults with attention‐deficit/hyperactivity disorder (ADHD), particularly whether benefits persist after treatment discontinuation, is not well understood. This study aimed to investigate whether prior medication history is associated with different patterns of ...
Masaaki Shimizu, Shunsuke Takagi, Ryuta Aoki, Takashi Itahashi, Yumi Shikauchi, Hironobu Nakamura, Genichi Sugihara, Hidehiko Takahashi, Motoaki Nakamura   +8 more
wiley   +1 more source

Impaired adrenergic regulation of Kv channels underlies LC hyperactivity and early‐onset sleep disruption in AD‐like amyloidogenic mice

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep–wake disturbances frequently occur at early stages of Alzheimer's disease (AD) and accelerate disease progression, but the underlying neural mechanisms are not fully understood. METHODS We examined sleep–wake behavior and locus coeruleus (LC) activity in young 5xFAD mice using electrophysiology and pharmacological approaches
Yi‐Ci Zhang, Xue‐Ting Zhang, Peng‐Yue Chen, Zi‐Yue Zhou, Mao‐Qing Huang, Kai‐Wen He   +5 more
wiley   +1 more source