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Noradrenergic Function in Suicide
Archives of Suicide Research, 2007Although abnormalities in serotonergic function have been the major focus of studies on suicidal behavior, several studies indicate that abnormalities of noradrenergic function may also be involved in the pathophysiology of suicide. In this paper, we have reviewed some of the noradrenergic studies in suicide, including studies of the biosynthetic ...
Yogesh Dwivedi, Ghanshyam N. Pandey
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Noradrenergic influences on catalepsy
Psychopharmacology, 1978Widespread depletion of forebrain noradrenaline, produced by the intracerebral injection of 4 microgram of 6-hydroxydopamine into the fibres of the dorsal noradrenergic bundle, potentiated the catalepsy induced by 20 mg/kg of morphine and severely attenuated the catalepsy induced by two separate cholinergic agonists, arecoline and pilocarpine.
Stephen T. Mason +2 more
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Noradrenergic modulation of lymphohematopoiesis
International Journal of Immunopharmacology, 1994Adrenergic agents can affect hematopoiesis after syngeneic bone marrow transplantation (BMT) in mice. In particular, chemical sympathectomy by 6-hydroxydopamine and/or administration of various doses of the alpha 1-adrenergic antagonist prazosin were shown to increase the concentration of blood granulocytes, platelets and bone marrow granulocyte ...
Georges J.M. Maestroni, Ario Conti
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Noradrenergic Function in Schizophrenia
Archives of General Psychiatry, 1987Yohimbine, an alpha 2-adrenergic receptor antagonist that increases noradrenergic function, was administered to 16 healthy subjects and 18 drug-free schizophrenic patients with (n = 10) and without (n = 8) tardive dyskinesia (TD). Outcome measures of this double-blind, placebo-controlled study included changes in behavior, plasma 3-methoxy-4-hydroxy ...
William M. Glazer +2 more
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Noradrenergic and adrenergic functioning in autism
Biological Psychiatry, 1994A neurochemical assessment of noradrenergic and adrenergic functioning was carried out with autistic patients and normal control individuals. Norepinephrine and related compounds were measured in autistic (n = 17 unmedicated, 23 medicated; age range 9-29 years old) and normal controls (n = 27; age range 9-36 years old).
Donald J. Cohen +4 more
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Noradrenergic and serotoninergic depression?
Journal of Affective Disorders, 1993The aim of this study was to test the hypothesis of noradrenergic and serotoninergic depressive subtypes. For this purpose, the correlation between three variables was investigated: urinary 3-methoxy-4-hydroxyphenylglycol (MHPG), dexamethasone suppression test (DST), and clinical response profiles to clomipramine and maprotiline, the effects of which ...
Alp Üçok +8 more
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AMPHETAMINE AND NORADRENERGIC REWARD PATHWAYS
Biochemical Pharmacology, 1973Publisher Summary This chapter reviews amphetamine and noradrenergic reward pathways. The effects of norepinephrine, and dopamine on self-stimulation were directly examined by injecting these agents in the lateral ventricle through permanently-indwelling cannulas.
C. David Wise, Larry Stein
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Progress in Neurobiology, 2006
Norepinephrine is involved in intrinsic control of pain. Main sources of norepinephrine are sympathetic nerves peripherally and noradrenergic brainstem nuclei A1-A7 centrally. Peripheral norepinephrine has little influence on pain in healthy tissues, whereas in injured tissues it has variable effects, including aggravation of pain.
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Norepinephrine is involved in intrinsic control of pain. Main sources of norepinephrine are sympathetic nerves peripherally and noradrenergic brainstem nuclei A1-A7 centrally. Peripheral norepinephrine has little influence on pain in healthy tissues, whereas in injured tissues it has variable effects, including aggravation of pain.
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Genetic Manipulation of Noradrenergic Neurons
The Journal of Pharmacology and Experimental Therapeutics, 2002The neurotransmitter norepinephrine has been the focus of intense investigation for nearly a century. With advances in technology come novel approaches for testing hypotheses about the physiological roles of norepinephrine and the genes involved in norepinephrine (NE) biosynthesis, metabolism, and noradrenergic signaling.
David Robertson, Robert P. Carson
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Noradrenergic mechanisms in the prefrontal cortex
Journal of Psychopharmacology, 1997There is growing evidence that noradrenergic inputs to the prefrontal cortex (PFC) play an important role in regulating its function. This paper reviews the pharmacological control of noradrenaline (NA) release in this region, with particular reference to our studies using brain microdialysis, and also describes how NA levels are modulated by ...
M. D. Lalies +3 more
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