Results 71 to 80 of about 7,845 (216)

Simplified models of pacemaker spiking in raphe and locus coeruleus neurons [PDF]

arXiv, 2015
Many central neurons, and in particular certain brainstem aminergic neurons exhibit spontaneous and fairly regular spiking with frequencies of order a few Hz. A large number of ion channel types contribute to such spiking so that accurate modeling of spike generation leads to the requirement of solving very large systems of differential equations ...
arxiv  

Cortical Effects of Dopamine Replacement Account for Clinical Response Variability in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Individual variability in clinical response to dopamine replacement therapy (DRT) is a key barrier to efficacious treatment for patients with Parkinson's disease (PD). A better understanding of the neurobiological sources of such interindividual differences is necessary to personalize DRT prescribing, inform future clinical ...
Alex I. Wiesman, Mikkel C. Vinding, Panagiota Tsitsi, Per Svenningsson, Josefine Waldthaler, Daniel Lundqvist   +5 more
wiley   +1 more source

Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract

NeuroImage, 2022
The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal and attention. Recent studies have examined the microstructural properties of the LC using diffusion-weighted magnetic resonance imaging and found unexpected age ...
Shai Porat, Francesca Sibilia, Josephine Yoon, Yonggang Shi, Martin J. Dahl, Markus Werkle-Bergner, Sandra Düzel, Nils Bodammer, Ulman Lindenberger, Simone Kühn, Mara Mather   +10 more
doaj  

Molecular‐Informed Network Analysis Unveils Fatigue‐Related Functional Connectivity in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Fatigue in Parkinson's disease (PD) is a prevalent and debilitating non‐motor symptom. Despite its significant impact on quality of life, the underlying neurochemical and network‐based mechanisms remain poorly understood. Objectives This observational study applied a multimodal imaging approach to explore potential links between the
Ilaria Antonella Di Vico, Manuela Moretto, Agnese Tamanti, Giovanni Tomelleri, Giulia Burati, Daniel Martins, Ottavia Dipasquale, Mattia Veronese, Alessandra Bertoldo, Elisa Menini, Angela Sandri, Sarah Ottaviani, Francesca Benedetta Pizzini, Michele Tinazzi, Marco Castellaro   +14 more
wiley   +1 more source

PGC‐1α Activation by Polyphenols: A Pathway to Thermogenesis

Molecular Nutrition &Food Research, EarlyView.
Polyphenols, derived from dietary sources such as berries, undergo digestion and interact with gut microbiota, leading to their metabolization in the liver. This process influences bile acid composition, which in turn activates PGC1α, a key regulator of mitochondrial biogenesis and thermogenesis.
Nicholas Vannuchi, Luciana Pisani
wiley   +1 more source

Copper and the brain noradrenergic system

JBIC Journal of Biological Inorganic Chemistry, 2019
Copper (Cu) plays an essential role in the development and function of the brain. In humans, genetic disorders of Cu metabolism may cause either severe Cu deficiency (Menkes disease) or excessive Cu accumulation (Wilson disease) in the brain tissue. In either case, the loss of Cu homeostasis results in catecholamine misbalance, abnormal myelination of ...
Martina Ralle, Katharina Schmidt, Katharina Schmidt, Clorissa Washington-Hughes, Svetlana Lutsenko   +4 more
openaire   +4 more sources

Noradrenergic activity in anticipatory nausea.

Psychosomatic Medicine, 1992
Two studies were conducted to examine the hypothesis that noradrenergic activity is a cause of the anticipatory nausea associated with cancer chemotherapy. In the first study concentrations of plasma 3-methoxy-4-hydroxyphenyl-glycol (MHPG) on day 1 of cycle 5 of initial chemotherapy were significantly higher in patients with than without anticipatory ...
Fetting, JH, Stefanek, ME, Sheidler, VR, Elsworth, JD, Piantadosi, S, Roth, RH   +5 more
openaire   +4 more sources

Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer’s disease and Parkinson’s disease

Translational Neurodegeneration
Background Degeneration of the locus coeruleus (LC) noradrenergic system contributes to clinical symptoms in Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Chen-Pei Lin, Irene Frigerio, John G. J. M. Bol, Maud M. A. Bouwman, Alex J. Wesseling, Martin J. Dahl, Annemieke J. M. Rozemuller, Ysbrand D. van der Werf, Petra J. W. Pouwels, Wilma D. J. van de Berg, Laura E. Jonkman   +10 more
doaj   +1 more source

Blood levels of neurotransmitters in Yusho patients: An approach via the descending pain inhibitory pathway for persistent sensory disturbance

The Journal of Dermatology, EarlyView.
Abstract Yusho, a dioxin poisoning incident in Japan, has resulted in patients experiencing persistent symptoms, including sensory disturbances, decades after the initial exposure. This study investigated the potential involvement of the descending pain inhibitory system in Yusho patients.
Miwa Ashida, Naoya Murayama, Yoshiyuki Kamio, Mariko Yozaki, Yutaka Kuwatsuka, Takeshi Nakahara, Hiroyuki Murota   +6 more
wiley   +1 more source

Effects of Noradrenergic Stimulation Upon Context-Related Extinction Learning Performance and BOLD Activation in Hippocampus and Prefrontal Cortex Differ Between Participants Showing and Not Showing Renewal

Frontiers in Behavioral Neuroscience, 2019
While the neural structures mediating context-related renewal of extinction are well established, the neurotransmitter systems processing renewal remain elusive.
Silke Lissek, Anne Klass, Martin Tegenthoff   +2 more
doaj   +1 more source