Results 71 to 80 of about 1,322 (181)

Trace analysis of fluoxetine and its metabolite norfluoxetine. Part I: Development of a chiral liquid chromatography–tandem mass spectrometry method for wastewater samples

, 2011
An enantioselective method for the determination of fluoxetine (a selective serotonin reuptake inhibitor) and its pharmacologically active metabolite norfluoxetine has been developed for raw and treated wastewater samples.
Barclay, Victoria K. H.,, I. Monika Johansson, Pettersson, Curt E.,, Tyrefors, Niklas L.,, Victoria K.H. Barclay, Johansson, I. Monika,, Niklas L. Tyrefors, Curt E. Pettersson   +7 more
core   +1 more source

Applications of electrophoresis for small enantiomeric drugs in real‐world samples: Recent trends and future perspectives

ELECTROPHORESIS, Volume 45, Issue 1-2, Page 55-68, January 2024.
Abstract Separation and identification of chiral molecules is a topic widely discussed in the literature and of fundamental importance, especially in the pharmaceutical and food fields, both from industrial and laboratory points of view. Several techniques are used to carry out these analyses, but high‐performance liquid chromatography is often the ...
Imran Ali, Miryam Perrucci, Luigi Ciriolo, Cristian D'Ovidio, Ugo de Grazia, Halil Ibrahim Ulusoy, Abuzar Kabir, Fabio Savini, Marcello Locatelli   +8 more
wiley   +1 more source

Regulation of Hippocampal GABAergic Transmission by Fluoxetine and Its Metabolite Norfluoxetine

Major depression is related to dysfunction of the GABAergic pathway. Interestingly, the antidepressant fluoxetine modifies GABAergic neurotransmission in human and animal models of depression. However, the effects of norfluoxetine (the main metabolite of
Jassiel Mejía-Piedras, Jesús García-Colunga, Andy Hernández-Abrego, Elizabeth Vázquez-Gómez   +3 more
core   +1 more source

modelling and simulation based on fluoxetine and norfluoxetine concentrations in milk: a milk concentration‐based prediction model

, 2014
AIMS: Population pharmacokinetic (pop PK) modelling can be used for PK assessment of drugs in breast milk. However, complex mechanistic modelling of a parent and an active metabolite using both blood and milk samples is challenging. We aimed to develop a
Shinya Ito, Kristensen, Judith H., Taddio, Anna, Begg, Evan J., Evan J. Begg, Ito, Shinya, Anna Taddio, Izhar Wallach, Kenneth F. Ilett, Tanigawara, Yusuke, Bournissen, Facundo G.arcia, Facundo Garcia Bournissen, Judith H. Kristensen, Tanoshima, Reo, Ilett, Kenneth F., Wallach, Izhar, Yusuke Tanigawara, Reo Tanoshima   +17 more
core   +1 more source

Toxicokinetics of the Antidepressant Fluoxetine and Its Active Metabolite Norfluoxetine in Caenorhabditis elegans and Their Comparative Potency

The nematode Caenorhabditis elegans is a valuable model for ecotoxicological research, yet limited attention has been given to understanding how it absorbs, distributes, metabolizes, and excretes chemicals. This is crucial for C.
Merel A. van der Most (17947632), Wouter Bakker (13747299), Sebastiaan Wesseling (137855), Nico W. van den Brink (8452881)   +3 more
core   +1 more source

A rapid HPLC-DAD method for the analysis of fluoxetine and norfluoxetine in plasma from overdose patients

, 2004
There is a need for fast, simple and reliable analytical methods for the analysis of fluoxetine and norfluoxetine in patients who voluntarily or involuntarily have taken an overdose of the drug.
Maria Addolorata Saracino, Francesca Bugamelli, RAGGI, MARIA AUGUSTA, G. Varani, M. A. Saracino, Cesare Sabbioni, C. Sabbioni, F. Bugamelli, Graziano Varani, MERCOLINI, LAURA, Salvatore Fanali, A. Musenga, Maria Augusta Raggi, S. Fanali, Laura Mercolini, Alessandro Musenga   +15 more
core   +1 more source

Enantioselective Determination of Fluoxetine and Norfluoxetine in Wastewater

, 2013
Microbial degradation of chiral compounds during wastewater treatment processes can be enantioselective and needs chiral analytical methodology to discriminate the biodegradation of both enantiomers. An enantioselective HPLC-FD method was developed and validated to monitor the degradation of fluoxetine (FLX) enantiomers by wastewater and the possible ...
Ribeiro, Ana R., Maia, Alexandra S., Moreira, Irina S., Afonso, Carlos, Castro, Paula M.L., Tiritan, Maria E.   +5 more
openaire   +1 more source

Sensitive, high-throughput gas chromatographic-mass spectrometric assay for fluoxetine and norfluoxetine in human plasma and its application to pharmacokinetic studies

, 1998
A sensitive, robust gas chromatographic-mass spectrometric assay suitable for use in pharmacokinetic or bioequivalence studies is presented for the selective serotonin reuptake inhibitor, fluoxetine, and its major metabolite, norfluoxetine (N ...
Franklin M.E., Addison R.S., Hooper W.D.
core   +1 more source

The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine.

, 1999
The selective serotonin reuptake inhibitor fluoxetine is administered as a racemic mixture, and R- and S-fluoxetine are metabolized in the liver by N-demethylation to R- and S-norfluoxetine, respectively.
Fjordside, L., Powell, K., Baumann, P., Jeppesen, U., Eap, C.B., Brøsen, K.   +5 more
core   +1 more source

Relationship between plasma concentrations of fluoxetine plus norfluoxetine and their effects on fish exploratory behaviour after 28 days of exposure.

, 2014
Exploratory behaviour was quantified in individual fish using the Novel Tank Diving Test. A) Number of transitions into the Top Area; B) number of transitions into the Middle Area; C) time spent in the Top Area; D) time spent in the Middle Area; E ...
John P. Sumpter (71802), Stewart F. Owen (462227), Matthew J. Winter (648284), Grace H. Panter (648285), Mariann Rand-Weaver (648286), Luigi Margiotta-Casaluci (637444), Anna de Polo (637443), Rob I. Cumming (648283)   +7 more
core   +1 more source