Results 51 to 60 of about 1,322 (181)
, 2005 The antidepressant fluoxetine is administered as racemic mixture of two enantiomers (S- and R-fluoxetine). While S- and R-fluoxetine are equipotent in blocking serotonin reuptake, the enantiomers of the demethylated metabolite, norfluoxetine, show marked
SPINA E. +4 more
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Neural Plasticity, 2014 Selective serotonin reuptake inhibitor medications are one of the most common treatments for mood disorders. In humans, these medications are taken orally, usually once per day. Unfortunately, administration of antidepressant medications in rodent models
Jodi L. Pawluski +6 more
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Drug‐facilitated crime: A review of findings between 2019 and 2023
Journal of Forensic Sciences, Volume 70, Issue 6, Page 2442-2464, November 2025.Abstract Drug‐facilitated crime (DFC) is a criminal act (e.g., assault, robbery, or sexual assault) in which the perpetrator uses drugs to impair the victim's ability to resist, remember, or recognize the crime being committed. Ethanol is commonly implicated in DFC casework, but limited data are published on other substances currently implicated in ...
Meaghan R. Hessler +2 more
wiley +1 more source
Heliyon, 2019 Along many decades, protected environments were targeted by the scientific community for ecological research and for the collection of scientific information related to environmental aspects and biodiversity.
Esteban Avigliano +15 more
doaj +1 more source
Effects of sodium fluoride on serum concentrations of selected psychotropic drugs
Journal of Forensic Sciences, Volume 70, Issue 5, Page 1939-1948, September 2025.Abstract Caution is imperative when interpreting drug concentrations in blood, plasma, or serum, given the potential variance in the distribution of a compound across these fluids. Preservatives, such as sodium fluoride, prove beneficial in preventing drug degradation in collected blood samples. This study aimed to examine the impact of sodium fluoride
Jennifer Liut +6 more
wiley +1 more source
, 2002 Factors affecting the plasma concentrations of the R- and S-enantiomers of fluoxetine and norfluoxetine were investigated in 131 adult patients receiving long-term fluoxetine, of 10 to 60 mg/d (mean, 24 +/- 10 mg/d).
JANNUZZI, GIOVANNA ALESSANDRIA +8 more
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Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder
Frontiers in Cellular Neuroscience, 2014 Allopregnanolone and its equipotent stereoisomer, pregnanolone (together termed ALLO), are neuroactive steroids that positively and allosterically modulate the action of gamma-amino-butyric acid (GABA) at GABAA receptors.
Graziano ePinna, Ann M Rasmusson
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Analytical Science Advances, Volume 6, Issue 1, June 2025.ABSTRACT Liquid chromatography–mass spectrometry (LC–MS) is a highly sophisticated analytical technique that has become indispensable for sample analysis across various scientific domains. In recent years, LC–MS has emerged as a cornerstone technology in comparative replicate sample analysis, particularly in the fields of proteomics, lipidomics and ...
Samyah Alanazi
wiley +1 more source
Molecular Brain, 2018 Leak K+ currents are mediated by two-pore domain K+ (K2P) channels and are involved in controlling neuronal excitability. Of 15 members of K2P channels cloned so far, TRAAK, TREK-1, and TREK-2 are temperature sensitive. In the present study, we show that
Viacheslav Viatchenko-Karpinski +2 more
doaj +1 more source