Results 41 to 50 of about 1,322 (181)

Serum fluoxetine and norfluoxetine levels support the safety of fluoxetine in overdose [PDF]

Annals of General Psychiatry, 2016
Previous literature has found fluoxetine to be relatively safe in overdose. This study hopes to examine this idea along with support from published pharmacokinetic information including serum fluoxetine and norfluoxetine levels based on information from a clinical case series.Four cases are presented along with vital abnormalities, electrocardiogram ...
Stephanie Pope, Solomon G. Zaraa
openaire   +2 more sources

Fluoxetine (ng/ml) and norfluoxetine (ng/ml) levels in blood plasma.

, 2013
Fluoxetine (ng/ml) and norfluoxetine (ng/ml) levels in blood plasma.
Liesbeth Reneman (301735), Chantal van Brunschot (356734), Tim Arentsen (356733), Gilles van Luijtelaar (356737), Judith R. Homberg (221999), Gerdien Korte-Bouws (356736), Pieter Schipper (356735), Jocelien D. A. Olivier (356729), Tom Blom (356732)   +8 more
core   +1 more source

Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids [PDF]

Proceedings of the National Academy of Sciences, 2004
Mice housed in social isolation exhibit a decreased response to γ-aminobutyric acid-mimetic drugs [i.e., pentobarbital (PTB)] associated with a down-regulation of telencephalic allopregnanolone (Allo) levels. In these mice, the PTB-induced loss of righting reflex is greatly reduced.
Graziano, Pinna, Erminio, Costa, Alessandro, Guidotti   +2 more
openaire   +2 more sources

Rules of Thumb for Estimating Drug Levels in Breast Milk: How Well Do They Work?

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 101-108, January 2026.
The American Academy of Pediatrics and the World Health Organization recommend exclusive breastfeeding for the first 6 months of life due to extensive benefits for the maternal–infant dyad. While over 90% of mothers initiate breastfeeding, continuation drops to 35% by 6 months, often due to concerns about medication safety.
Juliya Gasparyan, Philip O. Anderson, Tamorah Lewis, Cindy H. T. Yeung   +3 more
wiley   +1 more source

Anorectic Activity of Fluoxetine and Norfluoxetine in Rats: Relationship Between Brain Concentrations and In-vitro Potencies on Monoaminergic Mechanisms

, 1992
The present study was aimed at establishing the importance of brain monoamine uptake and release mechanisms in the anorectic activity of fluoxetine, relating them to the actual brain concentrations of the parent drug and its metabolite norfluoxetine ...
S Caccia, A Bizzi, G Coltro, T Mennini, S Garattini, E Frittoli, C Fracasso   +6 more
core   +1 more source

Acute Urinary Retention Following Low‐Dose Risperidone in a Young Woman: A Case Report

Case Reports in Psychiatry, Volume 2026, Issue 1, 2026.
Risperidone is a widely used antipsychotic for psychotic disorders and is also used as an adjunctive treatment for many psychiatric conditions. While acute urinary retention is more commonly associated with antipsychotics that have anticholinergic effects, it is a rare adverse effect of risperidone.
Obada Zain, Mhd Omar Iyoun, Jana Ebido, Salma Khadem Alsrouji, Youssef Latifeh, Toshiya Inada   +5 more
wiley   +1 more source

Norfluoxetine Is the only Metabolite of Fluoxetine in Zebrafish (Danio rerio) Embryos That Accumulates at Environmentally Relevant Exposure Scenarios

, 2020
Fluoxetine has been recognized as one of the most toxic pharmaceuticals in the aquatic environment. Since there is growing evidence that the toxic potential of fluoxetine in surface waters is markedly influenced by its own metabolism in aquatic species ...
Braunbeck, Thomas, Loerracher, Ann Kathrin, Zindler, Florian, Tisler, Selina, Zwiener, Christian   +4 more
core   +2 more sources

Fluoxetine Delivery for Wound Treatment Through an Integrated Bioelectronic Device—Pharmacokinetic Parameters and Safety Profile in Swine

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Wound infections are a significant medical challenge, often leading to chronicity or systemic infection. Selective serotonin reuptake inhibitors (SSRIs) have emerged as potential nonantibiotic candidates with demonstrated ability to limit growth and biofilm formation in Gram‐negative bacteria, in addition to their pro‐healing activity.
Anthony Gallegos, Houpu Li, Hsin-ya Yang, Guillermo Villa-Martinez, Itidal Bazzi, Samhitha Sathyanarayanan, Narges Asefifeyzabadi, Prabhat Baniya, Wan Shen Hee, Mohammadhossein Siadat, Elizabeth Chang, Sriansh Pasumarthi, Elham Aslankoohi, Mircea Teodorescu, Marcella Gomez, Marco Rolandi, Rivkah Isseroff, Suraiya Saleem   +17 more
wiley   +1 more source

Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus

Scientific Reports, 2017
Pharmaceuticals and personal care products (PPCPs) have been found in wastewater treatment plant (WWTP) effluents and their recipient watersheds. To assess the potential of WWTP effluents to alter fish behaviour, we caged male goldfish (Carassius auratus)
D. B. D. Simmons, E. S. McCallum, S. Balshine, B. Chandramouli, J. Cosgrove, J. P. Sherry   +5 more
doaj   +1 more source

Label‐Free Electrochemical Impedance Spectroscopy for Biosensing: Evolving Interfaces and Mechanistic Insights

Small Science, Volume 5, Issue 12, December 2025.
Electrochemical impedance spectroscopy‐based label‐free biosensors offer rapid, direct, and sensitive analyte detection by measuring impedance changes in real time. Innovations in nanoengineered electrode surfaces and biorecognition elements have enhanced their performance facilitating point‐of‐care applications, despite ongoing challenges in ...
Nandhinee Radha Shanmugam, Joshua Rainbow, Jeong‐Chan Lee, Pawan Jolly, Donald E. Ingber   +4 more
wiley   +1 more source