Results 21 to 30 of about 1,322 (181)

Unraveling Protracted Neuropsychiatric Symptoms in a Patient With Altered Post-Bariatric Pharmacokinetics: A Diagnostic Puzzle. [PDF]

Case Rep Psychiatry
Objective To report a complex case of serotonin toxicity that evolved into a persistent neuropsychiatric syndrome, complicating the differential diagnosis between protracted toxicity, prolonged SSRI discontinuation syndrome, acute hepatic porphyria, and functional neurological disorder (FND).
Ali A, Potts CE, May D.
europepmc   +2 more sources

Analysis of Adherence to Fluoxetine Treatment through its Plasma Concentration

Brazilian Journal of Pharmaceutical Sciences, 2023
Depression plays an important role in non-adherence to medical recommendations. Fluoxetine is a first line of depression treatment. This study aimed to evaluate adherence to drug therapy in fluoxetine users by different methods. A cross-section study was
Juliana Raquel Raasch, Tainara Gomes Vargas, Andressa Schmidt dos Santos, Roberta Ziles Hahn, Anne Caroline Cezimbra da Silva, Marina Venzon Antunes, Rafael Linden, Andresa Heemann Betti, Magda Susana Perassolo   +8 more
doaj   +1 more source

Assessing the Mechanism of Fluoxetine-Mediated CYP2D6 Inhibition

Pharmaceutics, 2021
Fluoxetine is still one of the most widely used antidepressants in the world. The drug is extensively metabolized by several cytochrome P450 (CYP450) enzymes and subjected to a myriad of CYP450-mediated drug interactions.
Malavika Deodhar, Sweilem B. Al Rihani, Lucy Darakjian, Jacques Turgeon, Veronique Michaud   +4 more
doaj   +1 more source

In vitro modulation of estrogen receptor activity by norfluoxetine [PDF]

Medicine and Pharmacy Reports, 2015
Background & Aims: Selective serotonin reuptake inhibitors (SSRIs) are antidepressants increasingly prescribed for pregnancy and postpartum depression. However, these compounds can cross the placenta and also pass into breast milk, thus reaching the fetus and infant during critical developmental stages, potentially causing adverse effects ...
LUPU, DIANA, POP, ANCA, CHERFAN, JULIEN, KISS, BÉLA, LOGHIN, FELICIA   +4 more
openaire   +2 more sources

Multiple Effects of Echinochrome A on Selected Ion Channels Implicated in Skin Physiology

Marine Drugs, 2023
Echinochrome A (Ech A), a naphthoquinoid pigment from sea urchins, is known to have anti-inflammatory and analgesic effects that have been suggested to be mediated by antioxidant activity and intracellular signaling modulation.
Sung Eun Kim, Elina Da Sol Chung, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Hyoung Kyu Kim, Joo Hyun Nam, Sung Joon Kim   +8 more
doaj   +1 more source

Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis [PDF]

Journal of Neurochemistry, 2019
AbstractInflammatory insult to the central nervous system (CNS) can lead to development of depression, and subsequently depression is the most frequent psychiatric comorbidity following ischemic stroke, often limiting recovery and rehabilitation in patients. The initiators of inflammatory pathways in the CNS are microglia activated in response to acute
Kamaldeep S. Dhami, Matthew A. Churchward, Glen B. Baker, Kathryn G. Todd   +3 more
openaire   +2 more sources

High risk of drug toxicity in social isolation stress due to liver dysfunction: Role of oxidative stress and inflammation

Brain and Behavior, 2021
Background: Previous studies have shown that social isolation stress (SIS) could associate with several systemic diseases; however, the role of SIS on liver dysfunction has yet to be established. This study aimed to investigate the effect of SIS on liver
Maziar Zahir, Siavash Shariatzadeh, Ayda Khosravi, Fatima Ahmed Alshaikh, Parichehr Moradi, Milad Ghaderi, Parsa Farsinejad, Parisa Afraz Louyeh, Saba Ilkhani, Pooria Nakhaei, Amin Taheri, Avid Farhang Fagheh, Reza Akhavan‐Sigari   +12 more
doaj   +1 more source

Different Classes of Antidepressants Inhibit the Rat α7 Nicotinic Acetylcholine Receptor by Interacting within the Ion Channel: A Functional and Structural Study

Molecules, 2021
Several antidepressants inhibit nicotinic acetylcholine receptors (nAChRs) in a non-competitive and voltage-dependent fashion. Here, we asked whether antidepressants with a different structure and pharmacological profile modulate the rat α7 nAChR through
Yorley Duarte, Maximiliano Rojas, Jonathan Canan, Edwin G. Pérez, Fernando González-Nilo, Jesús García-Colunga   +5 more
doaj   +1 more source

Unraveling the Molecular Reason of Opposing Effects of α-Mangostin and Norfluoxetine on TREK-2 at the Same Binding Site. [PDF]

ChemMedChem
TWIK‐related K+ channel (TREK)‐2 has been considered as a promising target for the development of new analgesics, and it was demonstrated that α‐mangostin, a potent activator of TREK‐2, shares a binding site with the well‐known inhibitor of TREK‐2, norfluoxetine.
Kim G, Van NTH, Nam JH, Lee W.
europepmc   +2 more sources

Quantitative cross-species extrapolation between humans and fish: the case of the anti-depressant fluoxetine. [PDF]

PLoS ONE, 2014
Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and environmental toxicology. However, do fish respond to pharmaceuticals as humans do?
Luigi Margiotta-Casaluci, Stewart F Owen, Rob I Cumming, Anna de Polo, Matthew J Winter, Grace H Panter, Mariann Rand-Weaver, John P Sumpter   +7 more
doaj   +1 more source