Results 11 to 20 of about 1,322 (181)

Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna

Arhiv za Higijenu Rada i Toksikologiju, 2020
The aim of this study was to investigate the oxidative and apoptotic potential of fluoxetine, a widely used antidepressant in Turkey and the world, and of its metabolite norfluoxetine on a model non-target organism, Daphnia magna to see how exposure to ...
Över Sevgi Başalan, Güven Celal, Taskin Eylem, Sevgiler Yusuf   +3 more
doaj   +2 more sources

Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast‐feeding [PDF]

British Journal of Clinical Pharmacology, 2005
AimsTo compare the disposition of fluoxetine and norfluoxetine enanantiomers in the mother, foetus and infant.MethodsBlood from pregnant women taking fluoxetine (n = 9), during pregnancy was sampled in the third trimester and at delivery (maternal and cord venous blood), and from the infants 48 h after delivery.
Kim, John, Riggs, K Wayne, Misri, Shaila, Kent, Nancy, Oberlander, Tim F, Grunau, Ruth E, Fitzgerald, Colleen, Rurak, Dan W   +7 more
openaire   +4 more sources

A novel chiral GC/MS method for the analysis of fluoxetine and norfluoxetine enantiomers in biological fluids

Journal of Pharmacy and Bioallied Sciences, 2012
Aims: A novel robust chiral gas chromatographic/mass spectrometric (GC/MS) method for the separation and measurement of fluoxetine and norfluoxetine enantiomers in urine and plasma was developed.
Janet Mifsud, Lino J Sghendo
doaj   +2 more sources

Behavioral Therapy and Fluoxetine Treatment in Aggressive Dogs: A Case Study [PDF]

Animals, 2020
Canine aggression is a major concern, affecting millions of people worldwide, and treatment can be challenging even for skilled veterinarians. Empiric use of fluoxetine is sometimes attempted, although few data regarding long-term effects in aggressive ...
Rosangela Odore, Diego Rendini, Paola Badino, Giulia Gardini, Giulia Cagnotti, Valentina Meucci, Luigi Intorre, Claudio Bellino, Antonio D’Angelo   +8 more
doaj   +4 more sources

Anorectic activity of fluoxetine and norfluoxetine in mice, rats and guinea-pigs

Journal of Pharmacy and Pharmacology, 1992
Abstract The present study aimed to establish the role of the metabolite norfluoxetine in the anorectic activity of fluoxetine, and to relate the anorectic doses (ED50) to the brain concentrations of the parent drug and its metabolite.
M, Anelli, A, Bizzi, S, Caccia, A M, Codegoni, C, Fracasso, S, Garattini   +5 more
openaire   +3 more sources

Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine [PDF]

Water, 2022
The occurrence of psychopharmaceuticals in aquatic ecosystems is a growing problem. Fluoxetine (FL) and its metabolite norfluoxetine (NF) are selective serotonin reuptake inhibitors. Although they may be potentially harmful to non-target species, available knowledge on the effects of NF is sparse, relative to FL. This study aimed at contributing to the
Pedro Rodrigues, Virgínia Cunha, Marta Ferreira, Maria Armanda Reis-Henriques, Luís Oliva-Teles, Laura Guimarães, António Paulo Carvalho   +6 more
openaire   +2 more sources

The impacts of natural product miltirone and the CYP2D6 pharmacogenetic phenotype on fluoxetine metabolism [PDF]

Frontiers in Pharmacology
Introduction: To study the effects of drug-induced CYP2D6 activity inhibition and genetic polymorphisms on fluoxetine metabolism, rat liver microsomes (RLMs) and SD rats were used to investigate the potential drug‒drug interactions (DDIs), and CYP2D6 ...
Xiaodan Zhang, Xiaodan Zhang, Qingqing Li, Qingqing Li, Xinwu Ye, Qing Chen, Chen Chen, Guoxin Hu, Likang Zhang, Lianguo Chen   +9 more
doaj   +2 more sources

High-performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring [PDF]

Frontiers in Pharmacology
IntroductionThe incidence and mortality rate from depression are increasing year by year, and depression has become the main cause of global health loss and disability. Currently, the treatment of depression mainly relies on drug intervention.
Jinglong Wang, Junjie Wang, Chenxiao Zhang, Guofei Li   +3 more
doaj   +2 more sources

Tracing Pharmaceuticals in Water Systems: Focus on Neurodegenerative and Psychiatric Treatments [PDF]

Journal of Xenobiotics
Pharmaceutical residues in aquatic ecosystems pose significant environmental and public health challenges. Identifying the presence and levels of these pharmaceuticals is crucial.
Paula Paíga, Cristina Delerue-Matos
doaj   +2 more sources

Fluoxetine and Norfluoxetine Revisited: New Insights into the Electrochemical and Spectroscopic Properties [PDF]

The Journal of Physical Chemistry A, 2009
The extent to which humans and wildlife are exposed to the vast array of anthropogenic chemicals and their degradation products, along with related naturally occurring compounds, is nowadays an important issue. The study of the physical-chemical properties of the compounds and/or degradation products is an important subject because some of them are ...
E Manuela, Garrido, Jorge, Garrido, Rita, Calheiros, M Paula M, Marques, Fernanda, Borges   +4 more
openaire   +5 more sources