Results 41 to 50 of about 419,995 (312)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Norms and normativity

open access: yesCalenda, 2017
Collective life is structured by norms. Even though such norms manifest as regularities for those who observe them, they also constitute rules to follow or ideals to mimic. May these norms be social, moral, or legal, they organize practices and orient judgments, especially in the economic sphere.
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Norm Contestation and Pragmatic Ethics: Evaluating the Rebuilding Norm in Libya

open access: yes, 2021
Approaches variously described as critical, reflexive, postpositivist, and agonistic constructivism reject the idea that the meaning of a norm can be fixed.
Donovan, Outi
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Norm Hatch Photograph Collection

open access: yes, 1943
Photograph of staff sergeant Norm T. Hatch offering water to a kitten. The kitten is beneath the tread of a large tank.
United States. Marine Corps.
core   +3 more sources

Normative framework for normative system change [PDF]

open access: yesInternational Joint Conference on Autonomous Agents and Multiagent Systems, 2009
Normative systems in a multiagent system must be able to evolve over time, for example due to actions creating or removing norms in the system. The only formal framework to evaluate and classify normative system change methods is the so-called AGM framework of theory change, which has originally been developed as a framework to describe and classify ...
BOELLA, Guido   +2 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Correspondence from Norm Smith [PDF]

open access: yes, 1983
Correspondence sent to Atiyeh from Oregon State Representative, Norm ...
Smith, Norm
core  

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