Results 61 to 70 of about 529,333 (248)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2007 "S 36758 Cpl Norm Durant N.T. Force Sigs Coomalie Creek [M obscured Sept 19]43".S 36758 Corporal Norm Durant.
Durant, Norm
core
An analysis of norm emergence in Axelrod's model [PDF]
, 2010 Norms are a valuable mechanism for establishing coherent cooperative behaviour in decentralised systems in which no central authority exists. One of the most influential formulations of norm emergence was proposed by Axelrod, who defined a model of norms
Mahmoud, Samhar +3 more
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Bernhard Waldenfels’ Responsive Phenomenology of the Alien: An Introduction and Review
Phenomenology & Practice, 2014 Not available. Please see .pdf file.
Norm Friesen
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Przywilej piotrowy w kanonicznym porządku prawnym
Kościół i Prawo, 2016 W zaprezentowanym opracowaniu autorka skoncentrowała uwagę na instytucji przywileju piotrowego funkcjonującej w kanonicznym porządku prawnym. Wykazała, iż instytucja ta znajduje umocowanie we władzy papieskiej pojmowanej w kategoriach Namiestnika ...
Paulina Szablińska
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Conflict-of-law Rules in Use in Case of a Conflict of Singular Decrees (can. 53)
Kościół i Prawo, 2015 The author of the presented article carried out an interpretation of can. 53 which includes two conflict-of-law rules to be used in case of a conflict of singular decrees. According to the analysis, the first rule included in can.
Ginter Dzierżon
doaj +1 more source