Results 81 to 90 of about 419,995 (312)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Fast Algorithms for Solving H-infinity-Norm Minimization Problems
, 2001 In this paper we propose an efficient computation approach to minimize the H-infinity-norm of a transfer-function matrix depending affinely on a set of free parameters.
Varga, Andras, Parrilo, Pablo
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Numerical Approach for the Frequency-Weighted Hankel-Norm Approximation
, 2001 We derive new projection formulas for the model reduction method based on the frequency-weighted Hankel norm approximation (FWHNA). These formulas extend the applicability of the FWHNA method to frequency weights expressed as antistable right/left ...
Varga, Andras
core
Ekuivalensi Norm-n dalam Ruang Rd [PDF]
, 2013 Sebuah ruang vektor dapat dilengkapi lebih dari satu buah norm. Hal yang sama juga berlaku pada perluasan dari konsep norm yaitu norm-n dengan n>=2 . Oleh karena itu diperlukan kajian mengenai konsep ekuivalensi antar norm-n tersebut. Terdapat dua
Akbar, Taufik
core
Conflict-of-law Rules in Use in Case of a Conflict of Singular Decrees (can. 53)
Kościół i Prawo, 2015 The author of the presented article carried out an interpretation of can. 53 which includes two conflict-of-law rules to be used in case of a conflict of singular decrees. According to the analysis, the first rule included in can.
Ginter Dzierżon
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Morality and Prosocial Behavior: the Role of Awareness, Responsibility and Norms in the Norm Activation Model [PDF]
, 2009 This paper examines the relationships between variables included in the Norm Activation Model of prosocial behaviour (NAM). Specifically, we evaluate the strength of two commonly used interpretations of this model, namely the NAM as a mediator model and ...
Judith I M De Groot +5 more
core +1 more source
Implications of Schizophrenia on the Consensual Capability to Enter into Marriage
Kościół i Prawo, 2018 One of the most important causes of marriage nullity is consensual incapacity, i.e. a prospective spouse’s inability to validly express marital consent in accordance with the requirements set out in the 1983 Code of Canon Law. Within the meaning of canon
Kamil Rutecki
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source