Results 71 to 80 of about 529,333 (248)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Implications of Schizophrenia on the Consensual Capability to Enter into Marriage
Kościół i Prawo, 2018 One of the most important causes of marriage nullity is consensual incapacity, i.e. a prospective spouse’s inability to validly express marital consent in accordance with the requirements set out in the 1983 Code of Canon Law. Within the meaning of canon
Kamil Rutecki
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
On the Complementarity between Law and Social Norm: A Model Analysis with Special Reference to the Liability Rule for Tort [PDF]
How the law and the social norm interact with each other in the legalized modern society, whether the law completely replaces the pre-existing social norm or they coexist, and whether their interaction achieves an efficient system of social rules or ...
Atsushi Tsuneki, Yoshinobu Zasu
core
Philosophical Inquiry in Education, 2022 To understand the significance of school closures and remote learning under pandemic conditions, it is important to acknowledge that home and school are much more than just different cognitive environments; they represent heterogeneous, even mutually ...
Norm Friesen
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
(SNP123) Norm Trout and Bob Johnson
, 1977 Records a conversation between Norm Trout and Bob Johnson, employees of the National Park Service at Shenandoah National Park. The men discuss various issues concerning access to the park, trail conditions and early settlers to the region, including Bob ...
Trout, Norm
core
Ekuivalensi Norm-n dalam Ruang Rd [PDF]
, 2013 Sebuah ruang vektor dapat dilengkapi lebih dari satu buah norm. Hal yang sama juga berlaku pada perluasan dari konsep norm yaitu norm-n dengan n>=2 . Oleh karena itu diperlukan kajian mengenai konsep ekuivalensi antar norm-n tersebut. Terdapat dua
Akbar, Taufik
core
Technical Evaluation Report 40: The International Learning Object Metadata Survey
International Review of Research in Open and Distributed Learning, 2004 A wide range of projects and organizations is currently making digital learning resources (learning objects) available to instructors, students, and designers via systematic, standards-based infrastructures.
Norm Friesen
doaj