Results 51 to 60 of about 419,995 (312)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Maximum norm a posteriori error estimate for a 2d singularly perturbed semilinear reaction-diffusion problem

open access: yes, 2008
A singularly perturbed semilinear reaction-diffusion equation, posed in the unit square, is discretized on arbitrary nonuniform tensor-product meshes. We establish a second-order maximum norm a posteriori error estimate that holds true uniformly in the ...
Kopteva, Natalia
core   +1 more source

Przywilej piotrowy w kanonicznym porządku prawnym

open access: yesKościół i Prawo, 2016
W zaprezentowanym opracowaniu autorka skoncentrowała uwagę na instytucji przywileju piotrowego funkcjonującej w kanonicznym porządku prawnym. Wykazała, iż instytucja ta znajduje umocowanie we władzy papieskiej pojmowanej w kategoriach Namiestnika ...
Paulina Szablińska
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

If they put Honolulu in Ireland [music] /

open access: yes, 1930
For voice and piano.; Caption title.; "... Norm Byron, writer of 'The guy that put the 'I' in Ireland' and 'I've got some watermelons'"--Cover.; Publication date approximated from publication date (1923) of 'The guy that put the I in Ireland' and other ...
Byron, Norm.
core  

Maximum norm a posteriori error estimation for parabolic problems using elliptic reconstructions

open access: yes, 2013
A semilinear second-order parabolic equation is considered in a regular and a singularly perturbed regime. For this equation, we give computable a posteriori error estimates in the maximum norm.
NATALIA KOPTEVA (12353197)   +5 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

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