Results 81 to 90 of about 6,131,287 (277)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Three-Stage Estimation of the Mean and Variance of the Normal Distribution with Application to an Inverse Coefficient of Variation with Computer Simulation

open access: yesMathematics, 2019
This paper considers sequentially two main problems. First, we estimate both the mean and the variance of the normal distribution under a unified one decision framework using Hall’s three-stage procedure. We consider a minimum risk point estimation
Ali Yousef, Hosny Hamdy
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Distribution-Free Normal Modal Logics

open access: yesLogics
This article initiates the semantic study of distribution-free normal modal logic systems, laying the semantic foundations and anticipating further research in the area. The article explores roughly the same area, though taking a different approach, as a
Chrysafis Hartonas
doaj   +1 more source

Design of a Quick Switching Sampling System Based on the Coefficient of Variation

open access: yesTechnologies, 2018
In this research, a quick switching sampling (QSS) system based on the coefficient of variation (CV) is developed, which utilizes information from present and previous lots to make a decision about the submitted lot of product.
Ching-Ho Yen   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Using a Log-normal Failure Rate Distribution for Worst Case Bound Reliability Prediction [PDF]

open access: yes, 2003
Prior research has suggested that the failure rates of faults follow a log normal distribution. We propose a specific model where distributions close to a log normal arise naturally from the program structure.
Bishop, P. G., Bloomfield, R. E.
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Externally studentized normal midrange distribution

open access: yesCiência e Agrotecnologia
The distribution of externally studentized midrange was created based on the original studentization procedures of Student and was inspired in the distribution of the externally studentized range.
Ben Dêivide de Oliveira Batista   +2 more
doaj   +1 more source

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