Results 91 to 100 of about 586,193 (290)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Testing the Master Constraint Programme for Loop Quantum Gravity III. SL(2,R) Models

, 2004
This is the third paper in our series of five in which we test the Master Constraint Programme for solving the Hamiltonian constraint in Loop Quantum Gravity.
Adams B G, Ashtekar A, B Dittrich, Bargmann V, Carey A Grundling H, Dittrich B, Dittrich B, Dittrich B, Dittrich B, Giulini D, Giulini D, Howe R, Howe R, Kempf A, Klauder J, Neunhöffer H, Okolow A Lewandowski J, Paterson A, Pier J P, Reed M, Repka J, Rovelli C, Rovelli C, Sahlmann H, Sahlmann H, Sahlmann H, Sahlmann H, Sahlmann H Thiemann T, Sahlmann H Thiemann T, Smolin L, T Thiemann, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Trunk M   +48 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Constraining the Effective Mass of Majorana Neutrino with Sterile Neutrino Mass for Inverted Ordering Spectrum

Advances in High Energy Physics, 2019
Inspired by the experimental anomalies in neutrino physics and recent oscillation data from short baseline and another neutrino experiment, the realization of one extra neutrino flavor seems to be favoring.
Jaydip Singh
doaj   +1 more source

Open-Shell Nuclei and Excited States from Multi-Reference Normal-Ordered Hamiltonians

, 2016
We discuss the approximate inclusion of three-nucleon interactions into ab initio nuclear structure calculations using a multi-reference formulation of normal ordering and Wick's theorem.
Calci, Angelo, Gebrerufael, Eskendr, Roth, Robert   +2 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Exploring atmospheric neutrino oscillations at ESSnuSB

Journal of High Energy Physics
This study provides an analysis of atmospheric neutrino oscillations at the ESSnuSB far detector facility. The prospects of the two cylindrical Water Cherenkov detectors with a total fiducial mass of 540 kt are investigated over 10 years of data taking ...
The ESSnuSB collaboration, J. Aguilar, M. Anastasopoulos, E. Baussan, A. K. Bhattacharyya, A. Bignami, M. Blennow, M. Bogomilov, B. Bolling, E. Bouquerel, F. Bramati, A. Branca, G. Brunetti, I. Bustinduy, C. J. Carlile, J. Cederkall, T. W. Choi, S. Choubey, P. Christiansen, M. Collins, E. Cristaldo Morales, P. Cupiał, H. Danared, J. P. A. M. de André, M. Dracos, I. Efthymiopoulos, T. Ekelöf, M. Eshraqi, G. Fanourakis, A. Farricker, E. Fasoula, T. Fukuda, N. Gazis, Th. Geralis, M. Ghosh, A. Giarnetti, G. Gokbulut, C. Hagner, L. Halić, M. Hooft, K. E. Iversen, N. Jachowicz, M. Jenssen, R. Johansson, E. Kasimi, A. Kayis Topaksu, B. Kildetoft, K. Kordas, A. Leisos, M. Lindroos, A. Longhin, C. Maiano, S. Marangoni, C. Marrelli, D. Meloni, M. Mezzetto, N. Milas, J. L. Muñoz, K. Niewczas, M. Oglakci, T. Ohlsson, M. Olvegård, M. Pari, D. Patrzalek, G. Petkov, Ch. Petridou, P. Poussot, A. Psallidas, F. Pupilli, D. Saiang, D. Sampsonidis, C. Schwab, F. Sordo, A. Sosa, G. Stavropoulos, R. Tarkeshian, F. Terranova, T. Tolba, E. Trachanas, R. Tsenov, A. Tsirigotis, S. E. Tzamarias, G. Vankova-Kirilova, N. Vassilopoulos, S. Vihonen, J. Wurtz, V. Zeter, O. Zormpa   +87 more
doaj   +1 more source

The fate of hints: updated global analysis of three-flavor neutrino oscillations

Journal of High Energy Physics, 2020
Our herein described combined analysis of the latest neutrino oscillation data presented at the Neutrino2020 conference shows that previous hints for the neutrino mass ordering have significantly decreased, and normal ordering (NO) is favored only at the
Ivan Esteban, M.C. Gonzalez-Garcia, Michele Maltoni, Thomas Schwetz, Albert Zhou   +4 more
doaj   +1 more source

The Charge Ordered State from Weak to Strong Coupling

, 1998
We apply the Dynamical Mean Field Theory to the problem of charge ordering. In the normal state as well as in the Charge Ordered (CO) state the existence of polarons, i.e.
A. Bianconi, A. Bianconi, A. Georges, A. J. Millis, B. K. Chakraverty, C. H. Chen, F. de Pasquale, H. Orland, J. K. Freericks, J. K. Freericks, J. K. Freericks, J. K. Freericks, J. M. Tranquada, M. Capone, M. Capone, M. E. Muller-Hartmann, M. Randeria, P. Calvani, P. Calvani, P. G. Radaelli, P. Wochner, R. Micnas, S. Aubry, S. Ciuchi, S. Ciuchi, S. Ciuchi, S. Ciuchi, T. Holstein, T. Holstein, T. Katsufuji   +29 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source