Results 121 to 130 of about 1,588,486 (313)

Surface Roughness Tuning at Sub-Nanometer Level by Considering the Normal Stress Field in Magnetorheological Finishing. [PDF]

Micromachines (Basel), 2021
Li X, Li Q, Ye Z, Zhang Y, Ye M, Wang C.
europepmc   +1 more source

Adiposity is associated with blunted cardiovascular, neuroendocrine and cognitive responses to acute mental stress

, 2012
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited - Copyright @ 2012
Vivek Muthurangu, Jones, Alexander, Muthurangu Vivek, Deanfield, John E., McMillan Merlin R., Andrew M Taylor, Muthurangu, Vivek, Jones, RW, Jens C Pruessner, Steeden Jennifer A., Deanfield John E., Grzegorz T Kowalik, Taylor Andrew M., Taylor, Andrew M., Alexander Jones, Jones Alexander, Steeden, JA, Russell W Jones, Jones, Russell W., Merlin R McMillan, Muthurangu, V, Kowalik, GT, John E Deanfield, Pruessner, Jens C., Pruessner, JC, McMillan, MR, Deanfield, JE, Kowalik, Grzegorz T., Jones Russell W., Kowalik Grzegorz T., McMillan, Merlin R., Jones, A, Pruessner Jens C., Taylor, AM, Steeden, Jennifer A., Jennifer A Steeden   +35 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Effects of Paecilomyces lilacinus and Bacillus pumilus on stem nematode and rhizosphere bacterial communities of sweet potato

Scientific Reports
Stem nematode (Ditylenchus destructor Thorne) is considered one of the most economically devastating species affecting sweet potato production. Biocontrol offers a sustainable strategy for nematode control.
Fengyu Shi, Dan Yang, Xinpeng Meng, Jiaxin Li, Yingbo Zhu, Jianbin Liu   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Functional Characterization of Pomegranate CAMTA3 in Cold Stress Responses

Plants
Cold stress is a significant factor limiting plant growth and development. Pomegranate is particularly susceptible to low temperatures. Calmodulin-binding transcriptional activators (CAMTAs) are key regulators of cold stress tolerance in plants.
Shuangshuang Zhao, Rui Lu, Lijuan Feng, Mengyu Zheng, Han Zhang, Yanlei Yin, Ling Zheng   +6 more
doaj   +1 more source

Impact of statin use on major adverse cardiovascular events in patients with normal stress myocardial perfusion imaging and elevated coronary artery calcium score. [PDF]

Singapore Med J, 2023
To YH, Tan XM, Low CL, Min HH, Yew MS.
europepmc   +1 more source

Laboratory observations of transient frictional slip in rock-analog materials at co-seismic slip rates and rapid changes in normal stress

, 2012
Knowledge of frictional (shear) resistance and its dependency on slip distance, slip velocity, normal stress, and surface roughness is fundamental information for understanding earthquake physics and the energy released during such events.
Prakash V, 袁福平, Case Western Reserve Univ, Case Sch Engn, Dept Mech & Aerosp Engn, Cleveland, OH 44106 USA., Prakash, V   +3 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source