Results 201 to 210 of about 164,930 (254)

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu   +11 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng   +4 more
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani   +10 more
wiley   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane   +19 more
wiley   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni   +19 more
wiley   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran   +13 more
wiley   +1 more source

[How normal is 'normal'?].

open access: yesSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977
openaire   +1 more source

On the ‘most normal’ normal

Communications in Numerical Methods in Engineering, 2007
AbstractGiven a set of normals in ℛ3, two algorithms are presented to compute the ‘most normal’ normal. The ‘most normal’ normal is the normal that minimizes the maximal angle with the given set of normals. A direct application is provided supposing a surface triangulation is available.
Aubry, Romain, Löhner, Rainald
openaire   +1 more source

To normalize or not to normalize? Fat is the question

Environmental Toxicology and Chemistry, 1995
Abstract Concentrations of lipophilic contaminants in biota are frequently corrected for variation in tissue lipid content. Usually, this correction is accomplished by dividing tissue contaminant concentration by lipid concentration to form lipid-normalized data.
Craig E. Hebert, Karen A. Keenleyside
openaire   +1 more source

Amblyopia: The Normal Eye is Not Normal

Journal of Pediatric Ophthalmology & Strabismus, 1990
ABSTRACT When acuity was used to evaluate amblyopia in children, the amblyopic eye had decreased acuity and the nonamblyopic eye had normal acuity. However when Contrast Sensitivity Functions (CSFs) were used to evaluate amblyopia, losses in the CSF were discovered in both the amblyopic and the nonamblyopic eyes.
L E, Leguire, G L, Rogers, D L, Bremer
openaire   +2 more sources

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