Results 121 to 130 of about 7,704,118 (361)

Smooth Structures and Normalized Ricci Flows on Non-Simply Connected Four-Manifolds [PDF]

open access: yesarXiv, 2008
A solution to the normalized Ricci flow is called non-singular if it exists for all time with uniformly bounded sectional curvature. By using the techniques developed by the present authors, we study the existence or non-existence of non-singular solutions of the normalized Ricci flow on 4-manifolds with non-trivial fundamental group and the relation ...
arxiv  

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Normalized solutions of NLS equations with mixed nonlocal nonlinearities

open access: yesAdvances in Nonlinear Analysis
We study the existence and nonexistence of normalized solutions for the nonlinear Schrödinger equation with mixed nonlocal nonlinearities: −Δu=λu+μ(Iα∗∣u∣p)∣u∣p−2u+(Iα∗∣u∣q)∣u∣q−2uinRN,∫RN∣u∣2dx=c,\left\{\begin{array}{ll}-\Delta u=\lambda u+\mu \left({I ...
Zhang Zhenyu, Sun Juntao
doaj   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

open access: yesMolecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren   +4 more
wiley   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

open access: yesMolecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan   +6 more
wiley   +1 more source

Multiplicity of normalized semi-classical states for a class of nonlinear Choquard equations

open access: yesAdvances in Nonlinear Analysis
This article is concerned with the existence of multiple normalized solutions for a class of Choquard equations with a parametric perturbation −ε2Δu+V(x)u=λu+ε−α(Iα*F(u))f(u),x∈RN,∫RN∣u∣2dx=a2εN,\left\{\begin{array}{ll}-{\varepsilon }^{2}\Delta u+V\left ...
Wu Jinxia, He Xiaoming
doaj   +1 more source

On Normalized Ricci Flow and Smooth Structures on Four-Manifolds with $b^+=1$ [PDF]

open access: yesarXiv, 2008
We find an obstruction to the existence of non-singular solutions to the normalized Ricci flow on four-manifolds with $b^+=1$. By using this obstruction, we study the relationship between the existence or non-existence of non-singular solutions of the normalized Ricci flow and exotic smooth structures on the topological 4-manifolds ${\mathbb C}{P}^2 ...
arxiv  

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