Results 121 to 130 of about 299,484 (312)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Normalized homoclinic solutions of discrete nonlocal double phase problems

Bulletin of Mathematical Sciences
The aim of this paper is to discuss the existence of normalized solutions to the following nonlocal double phase problems driving by the discrete fractional Laplacian: ( − Δ𝔻)pαu(k) + μ(−Δ 𝔻)qβu(k) + ω(k)|u(k)|p−2u(k) = λ|u(k)|q−2u(k) + h(k)|u(k)|r−2u(k)
Mingqi Xiang, Yunfeng Ma, Miaomiao Yang
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Normalized Solutions for a SchröDinger Equation With Van Der Waals Type Potentials and External Potential: Mass Supercritical [PDF]

Jianqing Chen, Zhewen Chen
openalex   +1 more source

Normalized vector solutions of nonlinear Schrödinger systems

Discrete and Continuous Dynamical Systems
23 pages, 1 ...
Huang, Xiaomeng, Pistoia, Angela, Troestler, Christophe, Wang, Chunhua   +3 more
openaire   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Existence of normalized peak solutions for a coupled nonlinear Schrödinger system [PDF]

Jing Yang
openalex   +1 more source

Normalized solutions for nonlinear Schrödinger systems on bounded domains [PDF]

, 2019
Benedetta Noris, Hugo Tavares, Gianmaria Verzini   +2 more
openalex   +1 more source

Normalized solutions for nonlinear fractional Kirchhoff type systems

, 2022
Lingzheng Kong, Haibo Chen
openalex   +1 more source