Results 121 to 130 of about 294,135 (314)

Normalized Solutions to Schrödinger Systems with Potentials

open access: yesBulletin of the Iranian Mathematical Society
In this paper, we study the normalized solutions of the Schrödinger system with trapping potentials \begin{equation}\label{eq:diricichlet} \begin{cases} -Δu_1+V_1(x)u_1-λ_1 u_1=μ_1 u_1^3+βu_1u_2^{2}+κu_2~\hbox{in}~ \mathbb{R}^3,\\ -Δu_2+V_2(x)u_2-λ_2 u_2=μ_2 u_2^3+βu_1^2u_2+κu_1~\hbox{in}~ \mathbb{R}^3, u_1\in H^1(\mathbb{R}^3), u_2\in H^1(\mathbb{R ...
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Blow-up solutions to the Hartree-Fock type Schrödinger equation with the critical rotational speed

open access: yesAdvances in Nonlinear Analysis
In this article, we are concerned with the existence, non-existence, and blow-up behavior of normalized ground state solutions for the mass critical Hartree-Fock type Schrödinger equation with rotation i∂tu=−Δu+2V(x)u+2ΩLzu−λu−bu∫RN∣u(y)∣2∣x−y∣2dy,(t,x ...
Tu Yuanyuan, Wang Jun
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Normalized solutions for nonlinear Schrödinger systems with critical exponents

open access: yesAdvanced Nonlinear Studies
In this paper, we consider the following nonlocal Schrödinger system−a+b∫R3|∇u1|2dxΔu1=λ1u1+μ1|u1|p1−2u1+βr1|u1|r1−2u1|u2|r2,−a+b∫R3|∇u2|2dxΔu2=λ2u2+μ2|u2|p2−2u2+βr2|u1|r1|u2|r2−2u2,∫R3|u1|2dx=c1,∫R3|u2|2dx=c2.
Hu Jiaqing, Mao Anmin
doaj   +1 more source

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