Results 121 to 130 of about 8,131,330 (355)
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Normalized solutions of NLS equations with mixed nonlocal nonlinearities
Advances in Nonlinear AnalysisWe study the existence and nonexistence of normalized solutions for the nonlinear Schrödinger equation with mixed nonlocal nonlinearities: −Δu=λu+μ(Iα∗∣u∣p)∣u∣p−2u+(Iα∗∣u∣q)∣u∣q−2uinRN,∫RN∣u∣2dx=c,\left\{\begin{array}{ll}-\Delta u=\lambda u+\mu \left({I ...
Zhang Zhenyu, Sun Juntao
doaj +1 more source
The effect of sodium citrate 4% locking solution for central venous dialysis catheter on the international normalized ratio (INR) value [PDF]
, 2008 Julien Rioux +3 more
openalex +1 more source
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Multiplicity of normalized semi-classical states for a class of nonlinear Choquard equations
Advances in Nonlinear AnalysisThis article is concerned with the existence of multiple normalized solutions for a class of Choquard equations with a parametric perturbation −ε2Δu+V(x)u=λu+ε−α(Iα*F(u))f(u),x∈RN,∫RN∣u∣2dx=a2εN,\left\{\begin{array}{ll}-{\varepsilon }^{2}\Delta u+V\left ...
Wu Jinxia, He Xiaoming
doaj +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Solution of rank deficient normals
, 1981 Technical note written as input to the early studies of the ESA space astrometry project Hipparcos.
openaire +2 more sources
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source