Results 141 to 150 of about 7,704,118 (361)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Multiplicity of Normalized Solutions to a Fractional Logarithmic Schrödinger Equation

Fractal and Fractional
We study the existence and multiplicity of normalized solutions to the fractional logarithmic Schrödinger equation (−Δ)su+V(ϵx)u=λu+ulogu2inRN, under the mass constraint ∫RN|u|2dx=a.
Yan-Cheng Lv, Gui-Dong Li
doaj   +1 more source

Multiple normalized solutions for a Sobolev critical Schrödinger-Poisson-Slater equation

, 2021
Louis Jeanjean, Thanh Trung Le
openalex   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

COMP Report: CPQR technical quality control guidelines for use of positron emission tomography/computed tomography in radiation treatment planning

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Positron emission tomography with x‐ray computed tomography (PET/CT) is increasingly being utilized for radiation treatment planning (RTP). Accurate delivery of RT therefore depends on quality PET/CT data. This study covers quality control (QC) procedures required for PET/CT for diagnostic imaging and incremental QC required for RTP.
Ran Klein, Mike Oliver, Dan La Russa, John Agapito, Stewart Gaede, JeanPierre Bissonnette, Arman Rahmim, Carlos Uribe   +7 more
wiley   +1 more source

Multiple normalized solutions for $(2,q)$-Laplacian equation problems in whole $\mathbb{R}^{N}$

Electronic Journal of Qualitative Theory of Differential Equations
This paper considers the existence of multiple normalized solutions of the following $(2,q)$-Laplacian equation: \begin{equation*} \begin{cases} -\Delta u-\Delta_q u=\lambda u+h(\epsilon x)f(u), &\mathrm{in}\ \mathbb{R}^{N},\\ \int_{\mathbb{R}^{N}}|u|^
Renhua Chen, Li Wang, Xin Song
doaj   +1 more source

A normalized algorithm for the solution of sparse symmetric seven-diagonal linear systems of semi-bandwidths M and P

, 1981
Elias A. Lipitakis
openalex   +1 more source

Multiple positive normalized solutions for nonlinear Schrödinger systems [PDF]

, 2018
Tianxiang Gou, Louis Jeanjean
openalex   +1 more source

Levothyroxine Sodium Oral Solution Normalizes Thyroid Function in a Patient with Hashimoto’s Disease, Gastritis, Diabetic Gastroparesis, and Small Intestinal Bacterial Overgrowth (SIBO)

, 2021
Brittany Bohinc Henderson
openalex   +2 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source