Results 71 to 80 of about 299,484 (312)

On existence of multiple normalized solutions to a class of elliptic problems in whole $\mathbb{R}^N$ via penalization method [PDF]

, 2023
Claudianor O. Alves, Nguyen Van Thin
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Normalized solutions for the Kirchhoff equation with combined nonlinearities in ℝ4

Advances in Nonlinear Analysis
In this article, we study the following Kirchhoff equation with combined nonlinearities: −a+b∫R4∣∇u∣2dxΔu+λu=μ∣u∣q−2u+∣u∣2u,inR4,∫R4∣u∣2dx=c2,\left\{\begin{array}{l}-\left(a+b\mathop{\displaystyle \int }\limits_{{{\mathbb{R}}}^{4}}{| \nabla u| }^{2}{\rm ...
Qiu Xin, Ou Zeng-Qi, Tang Chun-Lei, Lv Ying   +3 more
doaj   +1 more source

Normalized solutions for Kirchhoff equations with Choquard nonlinearity: mass Super-Critical Case

Communications in Analysis and Mechanics
In the present paper, we investigated the existence of normalized solutions for the following Kirchhoff equation with Choquard nonlinearity$ \begin{equation*} -\Big(a+b\int_{\mathbb{R}^{3}}|\nabla u|^{2}dx\Big)\Delta u-\lambda u = \mu|u|^{q-2}u+(I_ ...
Zhi-Jie Wang, Hong-Rui Sun
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Normalized solutions for Sobolev critical fractional Schrödinger equation

Advances in Nonlinear Analysis
In the present study, we investigate the existence of the normalized solutions to Sobolev critical fractional Schrödinger equation: (−Δ)su+λu=f(u)+∣u∣2s*−2u,inRN,(Pm)∫RN∣u∣2dx=m2,\hspace{14em}\left\{\begin{array}{ll}{\left(-\Delta )}^{s}u+\lambda u=f ...
Li Quanqing, Nie Jianjun, Wang Wenbo, Zhou Jianwen   +3 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Normalized solutions for the double-phase problem with nonlocal reaction

Advances in Nonlinear Analysis
In this article, we consider the double-phase problem with nonlocal reaction. For the autonomous case, we introduce the methods of the Pohozaev manifold, Hardy-Littlewood Sobolev subcritical approximation, adding the mass term to prove the existence and ...
Cai Li, Zhang Fubao
doaj   +1 more source