Results 81 to 90 of about 490,657 (289)
, 2010 We determine the metallicity distribution function (MDF) of the Galactic halo based on metal-poor main-sequence turnoff-stars (MSTO) which were selected from the Hamburg/ESO objective-prism survey (HES) database.
A. Frebel +76 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
On Statistical Properties of a New Family of Geometric Random Graphs
Engineering ProceedingsWe define a new family of random geometric graphs which we call random covering graphs and study its statistical properties. To the best of our knowledge, this family of graphs has not been explored in the past.
Kedar Joglekar +2 more
doaj +1 more source
Validity of heavy traffic steady-state approximations in generalized Jackson Networks
, 2006 We consider a single class open queueing network, also known as a generalized Jackson network (GJN). A classical result in heavy-traffic theory asserts that the sequence of normalized queue length processes of the GJN converge weakly to a reflected ...
Gamarnik, David, Zeevi, Assaf
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Insurance loss model vs. meteorological loss index – how comparable are their loss estimates for European windstorms? [PDF]
Natural Hazards and Earth System SciencesWindstorms affecting Europe are among the natural hazards with the largest socio-economic impacts. Therefore, many sectors like society, the economy, or the insurance industry are highly interested in reliable information on associated impacts and losses.
J. Moemken +6 more
doaj +1 more source
On the Power-Law Tail in the Mass Function of Protostellar Condensations and Stars
, 2003 We explore the idea that the power-law tail in the mass function of protostellar condensations and stars arises from the accretion of ambient cloud material on to a condensation, coupled with a nonuniform (exponential) distribution of accretion lifetimes.
C. E. Jones, Pudritz, S. Basu
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source