Results 91 to 100 of about 2,302,141 (295)
Attention or memory deficits? An HIV study in Shanghai using local and norm-based controls
Frontiers in NeurologyObjectiveHIV-associated neurocognitive disorder is a major complication in people living with HIV (PLWH), with standardized neuropsychological tests being essential for clinical diagnosis.
Chuan Chen +4 more
doaj +1 more source
Impact of crime on economic development of the Russian regions
Russian Journal of Economics and Law, 2019 Objective: to analyze the impact of crime as a social capital measure on economic growth in the regions and municipalities of the Russian Federation.Methods: general scientific methods of analysis and synthesis; econometric modeling.Results: the paper ...
A. A. Shakirova, T. V. Kramin
doaj +1 more source
Two types of epistemic instrumentalism [PDF]
, 2019 Epistemic instrumentalism views epistemic norms and epistemic normativity as essentially involving the instrumental relation between means and ends. It construes notions like epistemic normativity, norms, and rationality, as forms of instrumental or ...
Côté-Bouchard, Charles
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Frontiers in SociologyThe article analyses how a norm scientific perspective can advance our understanding of cross-border regions and guide future directions of research.
Sara Svensson
doaj +1 more source
FORMS OF COHESION IN CONFINEMENT INSTITUTIONS
Russian Journal of Economics and Law, 2015 Objective: to identify the diversity of cohesion forms in confinement institutions.Methods: qualitative analyses based on in-depth semi-structured interviews.Results: the study included adaptation of Western methodologies of the cohesion phenomenon ...
E. D. Slobodenyuk, E. D. Volkova
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Are trailblazing trials for reducing cognitive decline putting the cart before the horse?
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Timothy Daly
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source