Results 41 to 50 of about 16,047 (285)

Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses

open access: yesmBio, 2020
Human noroviruses (HuNoV) are a leading cause of viral gastroenteritis worldwide and a significant cause of morbidity and mortality in all age groups.
Myra Hosmillo   +9 more
doaj   +1 more source

Characterization of New Recombinant Noroviruses [PDF]

open access: yesJournal of Clinical Microbiology, 2005
ABSTRACT Noroviruses are important etiologic agents of acute gastroenteritis and show great genetic diversity. To characterize more fully previously detected strains that could not be assigned unequivocally to one particular genotype based on the RNA polymerase, we have sequenced a region in the capsid gene and, in some cases, in the junction
Ambert Balay, K   +4 more
openaire   +3 more sources

Glycolysis Is an Intrinsic Factor for Optimal Replication of a Norovirus

open access: yesmBio, 2019
The metabolic pathways of central carbon metabolism, glycolysis and oxidative phosphorylation (OXPHOS), are important host factors that determine the outcome of viral infections and can be manipulated by some viruses to favor infection.
Karla D. Passalacqua   +8 more
doaj   +1 more source

Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to That of Receptors and Discriminates Particle Functionality

open access: yesmSphere, 2016
Although two in vitro cultivation methods have been reported, discrimination of infectious human norovirus particles for study of viral inactivation is still a challenge, as both rely on reverse transcriptase quantitative PCR.
Matthew D. Moore   +3 more
doaj   +1 more source

Epidemiology and evolution of rotaviruses and noroviruses from an archival WHO Global Study in Children (1976-79) with implications for vaccine design. [PDF]

open access: yesPLoS ONE, 2013
Prompted by the discovery of new gastrointestinal viruses, the NIH, NIAID and WHO investigated the etiology of acute diarrhea that occurred from 1976-1979 in a global cohort of infants and young children.
Lauren A Rackoff   +3 more
doaj   +1 more source

Development of a High-Efficiency Immunomagnetic Enrichment Method for Detection of Human Norovirus via PAMAM Dendrimer/SA-Biotin Mediated Cascade-Amplification

open access: yesFrontiers in Microbiology, 2021
Human norovirus is a common cause of acute gastroenteritis worldwide, and oysters have been found to be the main carriers for its spread. The lack of efficient pre-treatment methods has been a major bottleneck limiting the detection of viruses in oysters.
Junshan Gao   +15 more
doaj   +1 more source

Emerging and Re-Emerging Zoonoses of Dogs and Cats. [PDF]

open access: yes, 2014
Since the middle of the 20th century, pets are more frequently considered as "family members" within households. However, cats and dogs still can be a source of human infection by various zoonotic pathogens.
Chomel, Bruno B
core   +2 more sources

The molecular pathology of noroviruses [PDF]

open access: yesThe Journal of Pathology, 2014
AbstractNorovirus infection in humans typically results in acute gastroenteritis but may also occur in many animal species. Noroviruses are recognized as one of the most common causes of acute gastroenteritis in the world, being responsible for almost 20% of all cases.
Stephanie M, Karst   +2 more
openaire   +2 more sources

Noroviruses in Archival Samples

open access: yesEmerging Infectious Diseases, 2005
Application of recent techniques to detect current pathogens in archival effluent samples collected and concentrated in 1987 lead to the characterization of norovirus GGII.6 Seacroft, unrecognized until 1990 in a clinical sample. Retrospective studies will likely increase our knowledge about waterborne transmission of emerging pathogens.
Sylvain Skraber   +3 more
openaire   +5 more sources

Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo

open access: yesmSphere, 2016
Intrahost genetic diversity and replication error rates are intricately linked to RNA virus pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation during infections in vivo.
Armando Arias   +4 more
doaj   +1 more source

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