Results 51 to 60 of about 5,888 (174)
Detection of noroviruses in shellfish in the Netherlands [PDF]
International Journal of Food Microbiology, 2006 Shellfish from oyster farms in the Netherlands and imported from other European countries were examined for viral contamination. A method that allows sequence matching between noroviruses from human cases and shellfish was used. The samples of shellfish (n = 42) were analyzed using a semi-nested RT-PCR that had been optimized for detection of norovirus
Boxman, Ingeborg LA +6 more
openaire +3 more sources
mBio, 2020 Norovirus infections take a heavy toll on worldwide public health. While progress has been made toward understanding host responses to infection, the role of the gut microbiome in determining infection outcome is unknown.
N. V. Patin +5 more
doaj +1 more source
VIEW, EarlyView.Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley +1 more source
Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry
Mass Spectrometry Reviews, Volume 45, Issue 4, Page 800-828, July/August 2026.ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui +4 more
wiley +1 more source
Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms
mSphere, 2017 Ideal antiviral vaccines elicit antibodies (Abs) with broad strain recognition that bind to regions that are difficult to mutate for escape. Using 10 murine norovirus (MNV) strains and 5 human norovirus (HuNoV) virus-like particles (VLPs), we identified ...
Abimbola O. Kolawole +8 more
doaj +1 more source
Applying Distinct CDMS Strategies to Observe Nonclassical Virus Capsid Assembly
Journal of Mass Spectrometry, Volume 61, Issue 6, June 2026.ABSTRACT In conventional native mass spectrometry (MS), one faces severe limitations when challenged with heterogeneous, high‐mass samples, commonly failing to resolve clear peak distributions, and thus mass determination. Charge detection MS (CDMS) has emerged as a premier method to analyze these samples by determining mass‐to‐charge ratio (m/z) and ...
Lars Thiede +14 more
wiley +1 more source
Antiviral targets of human noroviruses [PDF]
Current Opinion in Virology, 2016 Human noroviruses are major causative agents of sporadic and epidemic gastroenteritis both in children and adults. Currently there are no licensed therapeutic intervention measures either in terms of vaccines or drugs available for these highly contagious human pathogens. Genetic and antigenic diversity of these viruses, rapid emergence of new strains,
Bv Venkataram, Prasad +8 more
openaire +2 more sources
Prevalence of acute intestinal infections and their role in human pathology (review)
Journal of Education, Health and Sport, 2019 Acute intestinal infections (AII) are one of the most common infectious diseases, the eighth most important cause of annual mortality among all age groups, and the fifth most common cause of death among children under 5 years of age worldwide. From 3 to
E. V. Kozishkurt
doaj +3 more sources
Organoids: From Bench to Bedside Applications
MedComm, Volume 7, Issue 6, June 2026.Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li +6 more
wiley +1 more source
Inhibition of noroviruses by piperazine derivatives [PDF]
Bioorganic & Medicinal Chemistry Letters, 2012 There is currently an unmet need for the development of small-molecule therapeutics for norovirus infection. The piperazine scaffold, a privileged structure embodied in many pharmacological agents, was used to synthesize an array of structurally-diverse derivatives which were screened for anti-norovius activity in a cell-based replicon system.
Dou, Dengfeng +6 more
openaire +3 more sources