Results 41 to 50 of about 8,445 (167)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

open access: yesVIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

The Role of the Gut Microbiome in Resisting Norovirus Infection as Revealed by a Human Challenge Study

open access: yesmBio, 2020
Norovirus infections take a heavy toll on worldwide public health. While progress has been made toward understanding host responses to infection, the role of the gut microbiome in determining infection outcome is unknown.
N. V. Patin   +5 more
doaj   +1 more source

Benchmarking State-of-the-Art Approaches for Norovirus Genome Assembly in Metagenome Sample

open access: yesBiology, 2023
A recently published article in BMCGenomics by Fuentes-Trillo et al. contains a comparison of assembly approaches of several noroviral samples via different tools and preprocessing strategies.
Dmitry Meleshko, Anton Korobeynikov
doaj   +1 more source

Pathophysiology of the gut–eye axis in a Sjögren's disease‐like dry eye mouse model: An exploratory evaluation of dietary heat‐treated Enterococcus faecalis FK‐23

open access: yesExperimental Physiology, EarlyView.
Abstract Sjögren's disease is an autoimmune disease characterized by severe dry eye, but its pathophysiology remains unclear. Non‐obese diabetic (NOD) mice develop Sjögren's disease‐like dry eye prior to the onset of diabetes. Although intestinal immune abnormalities precede diabetes in NOD mice, their relationship to dry eye remains poorly understood.
Kenji Goto   +3 more
wiley   +1 more source

Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses

open access: yes, 2015
Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains.
Koromyslova, A   +4 more
core   +1 more source

Molecular Characterization of Noroviruses Detected in Diarrheic Stools of Michigan and Wisconsin Dairy Calves: Circulation of Two Distinct Subgroups [PDF]

open access: yes, 2004
Noroviruses have emerged as the leading worldwide cause of acute non-bacterial gastroenteritis in humans. The presence of noroviruses in diarrheic stool samples from calves on Michigan and Wisconsin dairy farms was investigated by RT-PCR.
Lora E Hanson   +11 more
core   +1 more source

Diagnostic Accuracy of Immunochromatographic Tests for the Detection of Norovirus in Stool Specimens: a Systematic Review and Meta-Analysis

open access: yesMicrobiology Spectrum, 2021
Noroviruses are the leading cause of acute gastroenteritis in all age groups and constitute a major health and economic burden worldwide. This systematic review and meta-analysis aimed to determine the diagnostic accuracy of immunochromatographic tests ...
Seo Hee Yoon, Hye Rim Kim, Jong Gyun Ahn
doaj   +1 more source

Surface Composition and Temperature Interact to Shape Viral Survival and Growth

open access: yesEnvironmental Microbiology, Volume 28, Issue 9, September 2026.
Environmental surface type and temperature interact synergistically to shape viral survival and reproduction. Using bacteriophages T4 and φX174 on copper, steel and plastic at different temperatures, we demonstrate that survival and reproductive capacity are partially decoupled traits, with copper at 37°C causing rapid viral inactivation while their ...
Ketty Kabengele   +3 more
wiley   +1 more source

Review of Animal Noroviruses [PDF]

open access: yes, 2008
Among enteric caliciviruses, noroviruses belong to the genus Norovirus, one of the four accepted genera in the family Caliciviridae. These single-stranded, positive-sense RNA viruses are highly variable both genetically and antigenically.
Mauroy, A.   +3 more
core  

Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms

open access: yesmSphere, 2017
Ideal antiviral vaccines elicit antibodies (Abs) with broad strain recognition that bind to regions that are difficult to mutate for escape. Using 10 murine norovirus (MNV) strains and 5 human norovirus (HuNoV) virus-like particles (VLPs), we identified ...
Abimbola O. Kolawole   +8 more
doaj   +1 more source

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