Results 41 to 50 of about 15,637 (259)

Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures [PDF]

open access: yes, 2017
Vesivirus 2117 is an adventitious agent that in 2009, was identified as a contaminant of CHO cells propagated in bioreactors at a pharmaceutical manufacturing plant belonging to Genzyme.
Bhella, David   +8 more
core   +1 more source

Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to That of Receptors and Discriminates Particle Functionality

open access: yesmSphere, 2016
Although two in vitro cultivation methods have been reported, discrimination of infectious human norovirus particles for study of viral inactivation is still a challenge, as both rely on reverse transcriptase quantitative PCR.
Matthew D. Moore   +3 more
doaj   +1 more source

Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses

open access: yesmBio, 2020
Human noroviruses (HuNoV) are a leading cause of viral gastroenteritis worldwide and a significant cause of morbidity and mortality in all age groups.
Myra Hosmillo   +9 more
doaj   +1 more source

Interferon-lambda: A potent regulator of intestinal viral infections [PDF]

open access: yes, 2017
Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Baldridge, Megan T, Lee, Sanghyun
core   +3 more sources

Norovirus infection in immunocompromised hosts [PDF]

open access: yes, 2003
Acute gastroenteritis caused by noroviruses often has a duration of 2–0 days and is characteristically self-limiting. In contrast, chronic infection caused by noroviruses in immunocompromised individuals can last from weeks to years, making clinical ...
Direcció Tècnica d'Urbanisme   +1 more
core   +1 more source

The molecular pathology of noroviruses [PDF]

open access: yesThe Journal of Pathology, 2014
AbstractNorovirus infection in humans typically results in acute gastroenteritis but may also occur in many animal species. Noroviruses are recognized as one of the most common causes of acute gastroenteritis in the world, being responsible for almost 20% of all cases.
Stephanie M, Karst   +2 more
openaire   +2 more sources

Noroviruses in Archival Samples

open access: yesEmerging Infectious Diseases, 2005
Application of recent techniques to detect current pathogens in archival effluent samples collected and concentrated in 1987 lead to the characterization of norovirus GGII.6 Seacroft, unrecognized until 1990 in a clinical sample. Retrospective studies will likely increase our knowledge about waterborne transmission of emerging pathogens.
Sylvain Skraber   +3 more
openaire   +5 more sources

Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo

open access: yesmSphere, 2016
Intrahost genetic diversity and replication error rates are intricately linked to RNA virus pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation during infections in vivo.
Armando Arias   +4 more
doaj   +1 more source

Genetic characterization and phylogenetic analysis of human norovirus infection in individual municipalities of the Sverdlovsk region in 2022

open access: yesЖурнал микробиологии, эпидемиологии и иммунобиологии, 2023
Introduction. Human Noroviruses (HuNoV) are highly contagious pathogens responsible of acute human norovirus infection (HuNoVI). GII.4 is the prevailing norovirus genotype in the incidence of gastroenteritis worldwide.
Roman O. Bykov   +8 more
doaj   +1 more source

Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of IFN-lambda against norovirus and reovirus [PDF]

open access: yes, 2017
Lambda interferon (IFN-λ) has potent antiviral effects against multiple enteric viral pathogens, including norovirus and rotavirus, in both preventing and curing infection. Because the intestine includes a diverse array of cell types, however, the cell(s)
Baldridge, Megan T   +7 more
core   +2 more sources

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