Results 21 to 30 of about 8,445 (167)

Glycolysis Is an Intrinsic Factor for Optimal Replication of a Norovirus

open access: yesmBio, 2019
The metabolic pathways of central carbon metabolism, glycolysis and oxidative phosphorylation (OXPHOS), are important host factors that determine the outcome of viral infections and can be manipulated by some viruses to favor infection.
Karla D. Passalacqua   +8 more
doaj   +1 more source

Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to That of Receptors and Discriminates Particle Functionality

open access: yesmSphere, 2016
Although two in vitro cultivation methods have been reported, discrimination of infectious human norovirus particles for study of viral inactivation is still a challenge, as both rely on reverse transcriptase quantitative PCR.
Matthew D. Moore   +3 more
doaj   +1 more source

Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses

open access: yesmBio, 2020
Human noroviruses (HuNoV) are a leading cause of viral gastroenteritis worldwide and a significant cause of morbidity and mortality in all age groups.
Myra Hosmillo   +9 more
doaj   +1 more source

Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo

open access: yesmSphere, 2016
Intrahost genetic diversity and replication error rates are intricately linked to RNA virus pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation during infections in vivo.
Armando Arias   +4 more
doaj   +1 more source

Genetic characterization and phylogenetic analysis of human norovirus infection in individual municipalities of the Sverdlovsk region in 2022

open access: yesЖурнал микробиологии, эпидемиологии и иммунобиологии, 2023
Introduction. Human Noroviruses (HuNoV) are highly contagious pathogens responsible of acute human norovirus infection (HuNoVI). GII.4 is the prevailing norovirus genotype in the incidence of gastroenteritis worldwide.
Roman O. Bykov   +8 more
doaj   +1 more source

Noroviruses in food chain production [PDF]

open access: yes, 2016
Viruses, predominantly noroviruses, are progressively identified as the leading cause of foodborne diseases worldwide. In the Europe Union they have been determined as a main cause of foodborne outbreaks in 2014, while in the United States viruses are ...
Radin, Dragoslava
core   +1 more source

Study on norovirus contamination of live bivalve molluscs using real-time PCR

open access: yesBulgarian Journal of Veterinary Medicine, 2020
Foodborne and waterborne viruses are a major cause of human morbidity. Of them, noroviruses are recognised as the leading causative agents of sporadic infections and epidemic outbreaks of acute gastroenteritis in humans.
G. Krumova-Valcheva   +2 more
doaj   +1 more source

Bile Goes Viral

open access: yesViruses, 2021
Laboratory cultivation of viruses is critical for determining requirements for viral replication, developing detection methods, identifying drug targets, and developing antivirals.
Victoria R. Tenge   +8 more
doaj   +1 more source

Development of a High-Efficiency Immunomagnetic Enrichment Method for Detection of Human Norovirus via PAMAM Dendrimer/SA-Biotin Mediated Cascade-Amplification

open access: yesFrontiers in Microbiology, 2021
Human norovirus is a common cause of acute gastroenteritis worldwide, and oysters have been found to be the main carriers for its spread. The lack of efficient pre-treatment methods has been a major bottleneck limiting the detection of viruses in oysters.
Junshan Gao   +15 more
doaj   +1 more source

Attach Me If You Can: Murine Norovirus Binds to Commensal Bacteria and Fungi

open access: yesViruses, 2020
The presence of commensal bacteria enhances both acute and persistent infection of murine noroviruses. For several enteric viral pathogens, mechanisms by which these bacteria enhance infection involve direct interactions between the virus and bacteria ...
Jasmine L. Madrigal   +6 more
doaj   +1 more source

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