Results 1 to 10 of about 15,637 (259)

Recombinant Noroviruses Circulating in Spain from 2016 to 2020 and Proposal of Two Novel Genotypes within Genogroup I

Microbiology Spectrum, 2022
Noroviruses are the leading cause of sporadic cases and outbreaks of viral gastroenteritis. For more than 20 years, most norovirus infections have been caused by the pandemic genotype GII.4, yet recent studies have reported the emergence of recombinant ...
Noemi Navarro-Lleó, Cristina Santiso-Bellón, Roberto Gozalbo-Rovira   +2 more
exaly   +4 more sources

Porcine Noroviruses Related to Human Noroviruses [PDF]

Emerging Infectious Diseases, 2005
Detection of genogroup II (GII) norovirus (NoV) RNA from adult pigs in Japan and Europe and GII NoV antibodies in US swine raises public health concerns about zoonotic transmission of porcine NoVs to humans, although no NoVs have been detected in US ...
Sonia M Cheetham, Menira Souza
exaly   +5 more sources

Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine–Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2

MBio, 2017
The Norovirus genus contains important human pathogens, but the role of host pathways in norovirus replication is largely unknown. Murine noroviruses provide the opportunity to study norovirus replication in cell culture and in small animals.
Broc T Mccune, Jia Lu, James B Eaglesham
exaly   +4 more sources

Variable and conserved B cell epitopes of GII.4 human noroviruses [PDF]

Journal of Virology
Norovirus is a leading cause of acute gastroenteritis worldwide, imposing a major burden on public health and healthcare systems. Despite its significant medical impact, no licensed vaccines or specific antiviral therapies are currently available ...
Gabriel I. Parra, Lauren A. Ford-Siltz, Kelsey A. Pilewski, Kentaro Tohma, Michael Landivar, Joseph A. Kendra   +5 more
doaj   +2 more sources

GII.23/24/25 noroviruses recognize glycans via a conventional glycan-binding site [PDF]

Frontiers in Microbiology
IntroductionHuman noroviruses (HuNoVs) are genetically diverse RNA viruses that cause acute gastroenteritis, with genogroup II (GII) accounting for over 90% of global infections.
Hanbo Li, Hanbo Li, Xin Cong, Xin Cong, Xiaoman Sun, Jianxun Qi, Xinyu Li, Miao Jin, Zhaojun Duan   +8 more
doaj   +2 more sources

Human Norovirus Triggers Primary B Cell Immune Activation In Vitro

mBio, 2022
Human norovirus (HNoV) is a global health and socioeconomic burden, estimated to infect every individual at least five times during their lifetime. The underlying mechanism for the potential lack of long-term immune protection from HNoV infections is not
Carmen Mirabelli, Melissa K. Jones, Vivienne L. Young, Abimbola O. Kolawole, Irene Owusu, Mengrou Shan, Basel Abuaita, Holly Turula, Jose G. Trevino, Irina Grigorova, Steven K. Lundy, Costas A. Lyssiotis, Vernon K. Ward, Stephanie M. Karst, Christiane E. Wobus   +14 more
doaj   +1 more source

Lewis b antigen is a common ligand for genogroup I norovirus strains

FEBS Open Bio, 2022
Noroviruses are major causative agents of nonbacterial acute gastroenteritis in humans. Ten genogroups of noroviruses have been identified to date, among which genogroup I (GI) and genogroup II (GII) noroviruses are major pathogens for humans. GI and GII
Yuichi Someya
doaj   +1 more source

Understanding the relationship between norovirus diversity and immunity

Gut Microbes, 2021
Human noroviruses are the most common viral cause of acute gastroenteritis worldwide. Currently, there are no approved vaccines or specific therapeutics to treat the disease.
Lauren A. Ford-Siltz, Kentaro Tohma, Gabriel I. Parra   +2 more
doaj   +1 more source

Identification of compelling inhibitors of human norovirus 3CL protease to combat gastroenteritis: A structure-based virtual screening and molecular dynamics study

Frontiers in Chemistry, 2022
Human noroviruses (NV) are the most prevalent cause of sporadic and pandemic acute gastroenteritis. NV infections cause substantial morbidity and death globally, especially amongst the aged, immunocompromised individuals, and children.
Shan He, Shan He, Shan He, Alaa F. Nahhas, Alaa Hamed Habib, Mohammed Ali Alshehri, Saleh Alshamrani, Saeed A. Asiri, Mashael M. Alnamshan, Nawal Helmi, Nawal Helmi, Ibtesam Al-Dhuayan, Jawaher Almulhim, Ahmed M. Alharbi, Dongxiao Su, Ankita Kumari, Abdul Rahaman   +16 more
doaj   +1 more source

Antigenic structural analysis of bat and human norovirus protruding (P) domains [PDF]

Journal of Virology
Dayna L. Holroyd, Akhil Kumar, Eduardo Vasquez, Veronika Masic, Mark von Itzstein, John B. Bruning, Grant S. Hansman   +6 more
doaj   +2 more sources