Results 1 to 10 of about 8,806 (201)

Antiviral Potential of Plants Against Noroviruses [PDF]

Molecules, 2021
Human noroviruses, which belong to the enterovirus family, are one of the most common etiological agents of food-borne diseases. In recent years, intensive research has been carried out regarding the antiviral activity of plant metabolites that could be ...
Agnieszka Jama-Kmiecik, Jolanta Sarowska, Irena Choroszy-Krol   +2 more
exaly   +5 more sources

Norovirus inter-species transmission in an ex vivo model is dependent on virus internalization capacity [PDF]

Emerging Microbes and Infections
Human noroviruses (HuNoV) are the most common cause of viral gastroenteritis worldwide, causing sporadic cases and outbreaks. Noroviruses that infect wild and domestic animals, including pigs and dogs, are genetically related to human noroviruses ...
Nele Villabruna, Myra Hosmillo, Ian Goodfellow, Niklas Arnberg, Juan Bárcena, Silke Rautenschlein, Benjamin Heidrich, Andreas Beineke, Gisa Gerold   +8 more
doaj   +2 more sources

Recombinant Noroviruses Circulating in Spain From 2016 to 2020 and Proposal of Two Novel Genotypes Within Genogroup I.

Microbiology Spectrum, 2022
Noroviruses are the leading cause of sporadic cases and outbreaks of viral gastroenteritis. For more than 20 years, most norovirus infections have been caused by the pandemic genotype GII.4, yet recent studies have reported the emergence of recombinant ...
Javier Buesa, Jesus Rodriguez-Diaz, Cristina Santiso-Bellón   +2 more
exaly   +3 more sources

Variable and conserved B cell epitopes of GII.4 human noroviruses [PDF]

Journal of Virology
Norovirus is a leading cause of acute gastroenteritis worldwide, imposing a major burden on public health and healthcare systems. Despite its significant medical impact, no licensed vaccines or specific antiviral therapies are currently available ...
Gabriel I. Parra, Lauren A. Ford-Siltz, Kelsey A. Pilewski, Kentaro Tohma, Michael Landivar, Joseph A. Kendra   +5 more
doaj   +2 more sources

A Bayesian Model for Estimation of Virus Reduction in Potable Reuse Treatment Trains and Quantitative Microbial Risk Assessment of Waterborne Viral Pathogens. [PDF]

Risk Anal
ABSTRACT Understanding virus occurrence and reduction at advanced treatment facilities for potable water reuse constitutes a high‐priority research need to protect human health and to enhance available water supply alternatives. The objectives were to (1) determine log reduction values (LRVs) of 15 viruses by advanced wastewater treatment; (2) evaluate
Schijven JF, Teunis PFM, Betancourt WQ.
europepmc   +2 more sources

Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17. [PDF]

Protein Sci
Abstract Human noroviruses are a leading cause of acute gastroenteritis worldwide, yet the molecular principles governing antibody recognition of their highly repetitive capsid remain poorly understood. Here, we immunized mice with virus‐like particles (VLPs) from the pandemic GII.4 strain and the emergent GII.17 strain, generating monoclonal IgM and ...
Tagawa J, Yanaka S, Kato Y, Masuda A, Lee JM, Senoo A, Oyama K, Uchihashi T, Nishida M, Kusakabe T, Caaveiro JMM.   +10 more
europepmc   +2 more sources

Cross‐Neutralizing and Broadly Neutralizing Human Antibodies Against Nonenveloped Viruses [PDF]

Eur J Immunol
In this review article, Marchand et al. compare cross ‐ and broadly ‐neutralizing human antibodies against non ‐ enveloped viruses from several major families, discussing their structural characteristics, neutralization mechanisms and relevance for the development of antiviral vaccines and therapeutics.
Marchand S, Taouli S, McIlroy D.
europepmc   +2 more sources

Noroviruses Co-Opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine-Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2.

MBio, 2017
The Norovirus genus contains important human pathogens, but the role of host pathways in norovirus replication is largely unknown. Murine noroviruses provide the opportunity to study norovirus replication in cell culture and in small animals.
Lucy Thorne, Emily Condiff, Herbert W. Virgin   +2 more
exaly   +3 more sources

GII.23/24/25 noroviruses recognize glycans via a conventional glycan-binding site [PDF]

Frontiers in Microbiology
IntroductionHuman noroviruses (HuNoVs) are genetically diverse RNA viruses that cause acute gastroenteritis, with genogroup II (GII) accounting for over 90% of global infections.
Hanbo Li, Hanbo Li, Xin Cong, Xin Cong, Xiaoman Sun, Jianxun Qi, Xinyu Li, Miao Jin, Zhaojun Duan   +8 more
doaj   +2 more sources

Human Norovirus Triggers Primary B Cell Immune Activation In Vitro

mBio, 2022
Human norovirus (HNoV) is a global health and socioeconomic burden, estimated to infect every individual at least five times during their lifetime. The underlying mechanism for the potential lack of long-term immune protection from HNoV infections is not
Carmen Mirabelli, Melissa K. Jones, Vivienne L. Young, Abimbola O. Kolawole, Irene Owusu, Mengrou Shan, Basel Abuaita, Holly Turula, Jose G. Trevino, Irina Grigorova, Steven K. Lundy, Costas A. Lyssiotis, Vernon K. Ward, Stephanie M. Karst, Christiane E. Wobus   +14 more
doaj   +1 more source