A Survey of Analytical Techniques for Noroviruses
As the leading cause of acute gastroenteritis worldwide, human noroviruses (HuNoVs) have caused around 685 million cases of infection and nearly $60 billion in losses every year. Despite their highly contagious nature, an effective vaccine for HuNoVs has
Lingling Liu, Matthew D. Moore
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Patterns and Temporal Dynamics of Natural Recombination in Noroviruses
Noroviruses infect a wide range of mammals and are the major cause of gastroenteritis in humans. Recombination at the junction of ORF1 encoding nonstructural proteins and ORF2 encoding major capsid protein VP1 is a well-known feature of noroviruses ...
Yulia A. Vakulenko +2 more
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Acute nonbacterial gastroenteritis is ubiquitous, and noroviruses are considered to be among the most common etiological agents. Noroviruses affect people of all ages.
Asya Stoyanova
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A Bayesian Model for Estimation of Virus Reduction in Potable Reuse Treatment Trains and Quantitative Microbial Risk Assessment of Waterborne Viral Pathogens. [PDF]
ABSTRACT Understanding virus occurrence and reduction at advanced treatment facilities for potable water reuse constitutes a high‐priority research need to protect human health and to enhance available water supply alternatives. The objectives were to (1) determine log reduction values (LRVs) of 15 viruses by advanced wastewater treatment; (2) evaluate
Schijven JF, Teunis PFM, Betancourt WQ.
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Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report
Background Until today, classic human astroviruses have not been associated with central nervous system infections in immunocompetent patients. Case presentation A 16-month-old Caucasian girl presented with repetitive generalized seizures with a 4-day ...
Georgia Koukou +5 more
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A 3-year wastewater-based epidemiology study of noroviruses in Senegal. [PDF]
Norovirus is a leading cause of acute gastroenteritis worldwide due to its high contagiousness, widespread transmission, and the lack of treatment or vaccine. In Senegal, no routine community-level monitoring is performed, and most available data concern
Diaw N +7 more
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Porcine Noroviruses Related to Human Noroviruses
Detection of genogroup II (GII) norovirus (NoV) RNA from adult pigs in Japan and Europe and GII NoV antibodies in US swine raises public health concerns about zoonotic transmission of porcine NoVs to humans, although no NoVs have been detected in US ...
Qiu-Hong Wang +5 more
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Epidemiology and evolution of rotaviruses and noroviruses from an archival WHO Global Study in Children (1976-79) with implications for vaccine design. [PDF]
Prompted by the discovery of new gastrointestinal viruses, the NIH, NIAID and WHO investigated the etiology of acute diarrhea that occurred from 1976-1979 in a global cohort of infants and young children.
Lauren A Rackoff +3 more
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Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17. [PDF]
Abstract Human noroviruses are a leading cause of acute gastroenteritis worldwide, yet the molecular principles governing antibody recognition of their highly repetitive capsid remain poorly understood. Here, we immunized mice with virus‐like particles (VLPs) from the pandemic GII.4 strain and the emergent GII.17 strain, generating monoclonal IgM and ...
Tagawa J +10 more
europepmc +2 more sources
Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors
Proteases are a major enzyme group playing important roles in a wide variety of biological processes in life forms ranging from viruses to mammalians. The aberrant activity of proteases can lead to various diseases; consequently, host proteases have been
Kyeong-Ok Chang +4 more
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