Results 151 to 160 of about 178,608 (339)

Marine n‐3 Polyunsaturated Fatty Acids Mitigate Obesity Traits Through PRDM16‐Driven Gene–Nutrient Interaction and Spatiotemporal Scale Browning Process

open access: yesFood Frontiers, EarlyView.
This large cohort study of 45,664 participants from the UK Biobank provides strong epidemiological evidence that fish oil use was associated with 12% and 7% lower risks of obesity and high body fat percentage, respectively. Mechanistically, marine n‐3 polyunsaturated fatty acids mitigate obesity traits through PRDM16‐driven gene–nutrient interactions ...
Xiaohui Liu   +12 more
wiley   +1 more source

Wild‐Derived House Mice (Mus musculus) Are Able to Cope With a Constant Light Environment

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Exposure to altered nighttime lighting conditions has become common in today's modern world. Light at night disrupts circadian processes that govern feeding patterns, sleep/wake cycles, and metabolic homoeostasis, increasing the risk of developing pathologies associated with cardiometabolic disease. Yet, the underlying mechanism(s) responsible
Kevin Pham   +4 more
wiley   +1 more source

Borrelia and Genital Lichen Sclerosus: A Critical Review of the Evidence

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Lichen sclerosus (LSc) is a chronic inflammatory dermatosis that primarily affects the genitalia. Growing evidence supports chronic occlusive urine exposure as the principal pathogenic driver, though other mechanisms, including mechanical irritation, hormonal influences, autoimmunity, and infection, have been proposed.
Liang Zhi Wong   +4 more
wiley   +1 more source

STAT3-siRNA诱导前列腺癌细胞凋亡机制的探讨

open access: yesZhongguo shiyan zhenduanxue, 2007
目的探讨RNA干扰技术沉默STAT3基因表达诱导人前列腺癌细胞凋亡的机制。方法针对人STAT3mRNA序列设计合成编码干扰RNA(siRNA)的DNA模板,构建pSilencer 2.1-U6-STAT3-siRNA重组质粒,转染人前列腺癌细胞株PC3,采用Western blot、Northern blot观察STAT3基因表达抑制后Bcl-2,C-Myc与Cyclin D1表达的变化,并用流式细胞技术及吖啶橙染色方法观察细胞凋亡。结果成功构建pSilencer 2.1-U6-STAT3 ...
于浩, 张灵, 高丽芳, 赵雪俭
doaj  

Northern Blot

open access: yesProtocol Exchange, 2015
Shicheng Su, Shicheng Su, Di Huang
openaire   +1 more source

A Genome‐Wide Association Study of Colorectal Cancer Mortality Outcomes Among Individuals of African and Admixture Ancestry

open access: yesMolecular Carcinogenesis, EarlyView.
ABSTRACT African Americans have the highest colorectal cancer (CRC) mortality rates in the United States. We performed the first genome‐wide association study (GWAS) of overall and CRC‐specific mortality among African Americans with incident CRC to identify genetic contributors to CRC outcomes.
Thomas Lawler   +7 more
wiley   +1 more source

How can children and young people have a voice in urban treescapes?

open access: yesPeople and Nature, EarlyView.
Abstract Scientific understanding of climate change has, to date, failed to result in sufficient action. This paper proposes that a deficit model of top‐down learning and dissemination in relation to public engagement with science may be part of the problem, particularly when considering the attitudes, values and empowerment of children and young ...
Simon Carr   +10 more
wiley   +1 more source

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