Stability of Norwalk virus capsid protein interfaces evaluated by in-silico nanoindentation [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 Norwalk virus causes severe gastroenteritis for which there is currently no specific anti-viral therapy. A stage of the infection process is uncoating of the protein capsid to expose the viral genome and allow for viral replication.
Kevin J Boyd +3 more
doaj +3 more sources
Mucosal and Cellular Immune Responses to Norwalk Virus. [PDF]
J Infect Dis, 2015 Noroviruses are a leading cause of acute gastroenteritis worldwide. Mucosal and cellular immune responses remain poorly understood, with most studies of noroviruses having focused on serological responses to infection.We used saliva, feces, and peripheral blood mononuclear cells collected from persons who were administered Norwalk virus (NV) to ...
Ramani S +6 more
europepmc +5 more sources
Norwalk Virus Shedding after Experimental Human Infection [PDF]
Emerging Infectious Diseases, 2008 Noroviruses are the most common cause of viral gastroenteritis in the United States. To determine the magnitude and duration of virus shedding in feces, we evaluated persons who had been experimentally infected with Norwalk virus. Of 16 persons, clinical
Robert L. Atmar +6 more
doaj +3 more sources
Development of Norwalk virus-specific monoclonal antibodies with therapeutic potential for the treatment of Norwalk virus gastroenteritis. [PDF]
J Virol, 2013 ABSTRACT Passive immunoprophylaxis or immunotherapy with norovirus-neutralizing monoclonal antibodies (MAbs) could be a useful treatment for high-risk populations, including infants and young children, the elderly, and certain patients who are debilitated or immunocompromised.
Chen Z +7 more
europepmc +5 more sources
Prestress strengthens the shell of Norwalk virus nanoparticles. [PDF]
Nano Lett, 2011 We investigated the influence of the protruding domain of Norwalk virus-like particles (NVLP) on its overall structural and mechanical stability. Deletion of the protruding domain yields smooth mutant particles and our AFM nanoindentation measurements show a surprisingly altered indentation response of these particles.
Baclayon M +8 more
europepmc +6 more sources
Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease [PDF]
Bioorganic and Medicinal Chemistry Letters, 2011 The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease.
William Groutas +2 more
exaly +3 more sources
Secretory pathway antagonism by calicivirus homologues of Norwalk virus nonstructural protein p22 is restricted to noroviruses [PDF]
Virology Journal, 2012 Background Our previous report that the Norwalk virus nonstructural protein p22 is an antagonist of the cellular secretory pathway suggests a new aspect of norovirus/host interaction.
Sharp Tyler M +7 more
doaj +3 more sources
Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro. [PDF]
Antimicrob Agents Chemother, 2018 Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds
Kitano M +4 more
europepmc +2 more sources
Mapping and modeling of a strain-specific epitope in the Norwalk virus capsid inner shell. [PDF]
Virology, 2016 Noroviruses are diverse positive-strand RNA viruses associated with acute gastroenteritis. Cross-reactive epitopes have been mapped primarily to conserved sequences in the capsid VP1 Shell (S) domain, and strain-specific epitopes to the highly variable ...
Parra GI +6 more
europepmc +2 more sources
Application of salivary antibody immunoassays for the detection of incident infections with Norwalk virus in a group of volunteers. [PDF]
J Immunol Methods, 2015 Norovirus infection is the most common cause of acute gastroenteritis in developed countries. Developing an assay based on a non-invasive biomarker for detecting incident norovirus infections could improve disease surveillance and epidemiological ...
Griffin SM +6 more
europepmc +2 more sources