Results 1 to 10 of about 27,015 (248)
Development of Norwalk virus-specific monoclonal antibodies with therapeutic potential for the treatment of Norwalk virus gastroenteritis. [PDF]
J Virol, 2013 ABSTRACT Passive immunoprophylaxis or immunotherapy with norovirus-neutralizing monoclonal antibodies (MAbs) could be a useful treatment for high-risk populations, including infants and young children, the elderly, and certain patients who are debilitated or immunocompromised.
Chen Z +7 more
europepmc +5 more sources
Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
PLoS ONE, 2010 Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Tyler M Sharp +4 more
doaj +6 more sources
Norwalk Virus–specific Binding to Oyster Digestive Tissues [PDF]
Emerging Infectious Diseases, 2006 The primary pathogens related to shellfishborne gastroenteritis outbreaks are noroviruses. These viruses show persistence in oysters, which suggests an active mechanism of virus concentration.
Françoise S. Le Guyader +7 more
doaj +5 more sources
Norwalk Virus Shedding after Experimental Human Infection [PDF]
Emerging Infectious Diseases, 2008 Noroviruses are the most common cause of viral gastroenteritis in the United States. To determine the magnitude and duration of virus shedding in feces, we evaluated persons who had been experimentally infected with Norwalk virus. Of 16 persons, clinical
Robert L. Atmar +6 more
doaj +4 more sources
Norovirus vaccine against experimental human Norwalk Virus illness. [PDF]
N Engl J Med, 2011 Noroviruses cause epidemic and sporadic acute gastroenteritis. No vaccine is available to prevent norovirus illness or infection.We conducted a randomized, double-blind, placebo-controlled, multicenter trial to assess the safety, immunogenicity, and efficacy of an investigational, intranasally delivered norovirus viruslike particle (VLP) vaccine (with ...
Atmar RL +10 more
europepmc +6 more sources
Norwalk Virus -- Off and Running [PDF]
Canadian Journal of Infectious Diseases, 2003 JM Conly, BL Johnston
doaj +5 more sources
Stability of Norwalk virus capsid protein interfaces evaluated by in-silico nanoindentation [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 Norwalk virus causes severe gastroenteritis for which there is currently no specific anti-viral therapy. A stage of the infection process is uncoating of the protein capsid to expose the viral genome and allow for viral replication.
Kevin J Boyd +3 more
doaj +2 more sources
Norwalk virus-like particles as vaccines. [PDF]
Expert Rev Vaccines, 2010 Noroviruses (NoV) cause the great majority of epidemic nonbacterial gastroenteritis in humans. Expression of the capsid protein in recombinant systems, including insect and plant cells, yields assembly of virus-like particles (VLPs) that mimic the antigenic structure of authentic virions, and are relatively acid- and heat-stable.
Herbst-Kralovetz M, Mason HS, Chen Q.
europepmc +4 more sources
Mucosal and Cellular Immune Responses to Norwalk Virus. [PDF]
J Infect Dis, 2015 Noroviruses are a leading cause of acute gastroenteritis worldwide. Mucosal and cellular immune responses remain poorly understood, with most studies of noroviruses having focused on serological responses to infection.We used saliva, feces, and peripheral blood mononuclear cells collected from persons who were administered Norwalk virus (NV) to ...
Ramani S +6 more
europepmc +4 more sources
Prestress strengthens the shell of Norwalk virus nanoparticles. [PDF]
Nano Lett, 2011 We investigated the influence of the protruding domain of Norwalk virus-like particles (NVLP) on its overall structural and mechanical stability. Deletion of the protruding domain yields smooth mutant particles and our AFM nanoindentation measurements show a surprisingly altered indentation response of these particles.
Baclayon M +8 more
europepmc +5 more sources