Results 11 to 20 of about 1,857,836 (187)
Experimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity. [PDF]
Clin Vaccine Immunol, 2015 The human noroviruses (NoVs) are genetically diverse, rapidly evolving RNA viruses and are the major cause of epidemic gastroenteritis of humans. Serum antibodies that block the interaction of NoVs and NoV viruslike particles (VLPs) with host attachment ...
Czakó R +5 more
europepmc +2 more sources
Virology, 2015 Noroviruses are the most common cause of acute gastroenteritis in humans. Development of an effective vaccine is required for reducing their outbreaks. In order to develop a GI norovirus vaccine, Newcastle disease virus vectors, rLaSota and modified rBC,
Kim SH +4 more
europepmc +2 more sources
Norovirus vaccine against experimental human Norwalk Virus illness. [PDF]
N Engl J Med, 2011 Background Noroviruses cause epidemic and sporadic acute gastroenteritis. No vaccine is available to prevent norovirus illness or infection. Methods We conducted a randomized, double-blind, placebo-controlled, multicenter trial to assess the safety ...
Atmar RL +10 more
europepmc +2 more sources
Nihon rinsho. Japanese journal of clinical medicine, 2008 This datasheet on Norwalk virus covers Identity, Distribution, Hosts/Species Affected.
Haruko Shirato-Horikoshi, K. Katayama
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Proteins of Norwalk virus [PDF]
Journal of Virology, 1981 The proteins of the Norwalk virus were studied by polyacrylamide gel electrophoresis. Highly purified specifically immunoprecipitated virions appeared to contain a single primary structural protein with a molecular weight of 59,000. In addition, a soluble Norwalk viral protein with a molecular weight of 30,000 was identified in fecal specimens ...
H B, Greenberg +6 more
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Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered Norwalk virus. [PDF]
Clin Vaccine Immunol, 2012 An assay was developed to detect antibodies against two norovirus proteases among participants in a Norwalk virus (GI.1) challenge study. Prechallenge seroprevalence was lower against the protease from the homologous GI.1 virus than against protease from
Ajami NJ +10 more
europepmc +2 more sources
Norwalk virus-like particles as vaccines. [PDF]
Expert Rev Vaccines, 2010 Noroviruses (NoV) cause the great majority of epidemic nonbacterial gastroenteritis in humans. Expression of the capsid protein in recombinant systems, including insect and plant cells, yields assembly of virus-like particles (VLPs) that mimic the antigenic structure of authentic virions, and are relatively acid- and heat-stable.
Herbst-Kralovetz M, Mason HS, Chen Q.
europepmc +4 more sources
Serum hemagglutination inhibition activity correlates with protection from gastroenteritis in persons infected with Norwalk virus. [PDF]
Clin Vaccine Immunol, 2012 A hemagglutination inhibition (HAI) assay to assess serum antibody responses following Norwalk virus (NV) infection was developed. HAI activity increased significantly in individuals experimentally infected with NV (n = 18) and correlated with antibody ...
Czakó R +5 more
europepmc +2 more sources
Backbone and side-chain ¹H, ¹⁵N, and ¹³C resonance assignments of Norwalk virus protease. [PDF]
Biomol NMR Assign, 2012 Norovirus protease cleaves the virus-encoded polyprotein into six mature nonstructural proteins, presenting itself as an essential enzyme for the viral replication as well as an attractive target for the antiviral drug development. A deeper understanding
Takahashi D +4 more
europepmc +2 more sources
Norwalk Virus -- Off and Running [PDF]
Canadian Journal of Infectious Diseases, 2003 JM Conly, BL Johnston
doaj +3 more sources