Results 261 to 270 of about 94,967 (299)
Some of the next articles are maybe not open access.
Nanoneurotherapeutics approach intended for direct nose to brain delivery
Drug Development and Industrial Pharmacy, 2015Brain disorders remain the world's leading cause of disability, and account for more hospitalizations and prolonged care than almost all other diseases combined. The majority of drugs, proteins and peptides do not readily permeate into brain due to the presence of the blood-brain barrier (BBB), thus impeding treatment of these conditions.Attention has ...
Shadab, Md +3 more
openaire +2 more sources
Nose-to-brain peptide delivery – The potential of nanotechnology
Bioorganic & Medicinal Chemistry, 2018Nose-to-brain (N-to-B) delivery offers to protein and peptide drugs the possibility to reach the brain in a non-invasive way. This article is a comprehensive review of the state-of-the-art of this emerging peptide delivery route, as well as of the challenges associated to it.
Samaridou, Eleni, Alonso, Maria José
openaire +2 more sources
Nose-to-brain delivery of lamotrigine-loaded PLGA nanoparticles
Drug Delivery and Translational Research, 2019Direct nose-to-brain delivery of drugs and faster onset of action have made intra-nasal route a much sought-after alternative to conventional routes of drug delivery to the brain. Lamotrigine is used for the treatment and management of neuropathic pain, and in the present work, lamotrigine (LTG)-PLGA nanoparticles were developed for intra-nasal ...
Kuldeep Nigam +6 more
openaire +2 more sources
Olfactory perception, communication, and the nose-to-brain pathway
Physiology & Behavior, 2004The present paper's aim is of to give an overview about the basic knowledge as well as actual topics of olfaction--with a special regard on behavior. We summarize different functions of the nose and the olfactory system in human physiology and psychology. We will first describe the functional anatomy of the olfactory system in man.
Ursula, Stockhorst, Reinhard, Pietrowsky
openaire +2 more sources
Nose-to-Brain Targeting of Resveratrol Nanoformulations
Current Vascular PharmacologyAbstract: Resveratrol [RES] is a polyphenolic stilbene with therapeutic potential owing to its antioxidant, anti-inflammatory, neuroprotective, and cardioprotective properties. However, the very poor oral bioavailability, fast metabolism, and extremely low stability under physiological conditions pose a severe ...
Amir Bavafa +2 more
openaire +1 more source
NANOPLATFORMS CONCEIVED FOR NOSE-TO-BRAIN DRUG DELIVERY
2022Many approaches to brain delivery of bioactive compounds have emerged in recent years. Intranasal (IN) route is one of the newly focused delivery options for central nervous system (CNS) targeting, since this is the only way through which the brain is in connection with the outside environment.
Angela Bonaccorso +4 more
openaire +2 more sources
Brain and other central nervous system tumor statistics, 2021
Ca-A Cancer Journal for Clinicians, 2021Kimberly D Miller +2 more
exaly
Polymeric nanoparticles for efficient nose-to-brain delivery
NanoscaleBrain disorders affect over one billion people globally, presenting significant challenges for effective treatment due to the limited drug bioavailability in the brain. The graphical abstract was created with BioRender.
Marie Bolon +3 more
openaire +1 more source