Results 131 to 140 of about 296,712 (303)

Defined Matrices Reveal Epithelial‐ and Mesenchymal‐Specific Responses to Stiffness and Adhesion in Human iPSC‐Derived Intestinal Organoids

open access: yesAdvanced Materials, EarlyView.
Defined PEG hydrogels enable human iPSC‐derived intestinal organoid culture without Matrigel. PEG‐ and Matrigel‐cultured organoids both support duodenal‐like epithelial identity, but direct comparison reveals subtle epithelial differentiation‐marker shifts and stronger mesenchymal ECM‐remodeling/integrin programs in PEG.
Alicja Kuziola   +8 more
wiley   +1 more source

Exceptional Elasto‐Dielectric Properties in a Highly Flexible Dielectric Elastomer Composite: The Key Roles of Parallel Elastic Nanofibers

open access: yesAdvanced Materials Technologies, EarlyView.
Soft dielectric elastomer composites often face a trade‐off between enhanced dielectric properties and mechanical compliance. Here, a parallel‐aligned polyurethane nanofiber network embedded in PDMS creates a flexible, durable composite with increased permittivity, low modulus, and fatigue stability after 100,000 cycles.
Yi Ge   +9 more
wiley   +1 more source

Parameter Investigation for Stamp Manufacturing of Complex 3D Geometries Using Nanoimprint Lithography

open access: yesAdvanced Materials Technologies, EarlyView.
Nanoimprint lithography can replicate complex 3D microstructures with undercuts using single‐layer polymer stamps of different elasticities. By combining experiments and simulations, T‐shaped geometries and suitable undercut radii were identified that minimize stress and defects during demolding.
Christos Julianos Karapatzakis   +3 more
wiley   +1 more source

Notch at Implantation

open access: yesBiology of Reproduction, 2016
Implantation of the blastocyst involves numerous hormonal and cellular factors with Notch playing a key role, according to a new study suggesting that this developmental regulator may help modulate expression of the progesterone receptor. In previous studies, Asgi Fazleabas and colleagues have shown that conditionally deleting Notch1 in the mouse ...
openaire   +2 more sources

Micromachined Double‐Membrane Mechanically Tunable Metamaterial for Thermal Infrared Filtering

open access: yesAdvanced Photonics Research, Volume 6, Issue 5, May 2025.
Herein, a mechanically tunable double‐layer plasmonic metamaterial leveraging the extraordinary optical transmission effect observed in subwavelength arrays of openings within thin metal layers is presented. The concept is experimentally validated by integrating the proposed metamaterial structure into an electrostatic parallel‐plate actuator to create
Oleg Bannik   +7 more
wiley   +1 more source

Continuum Mechanics Modeling of Flexible Spring Joints in Surgical Robots

open access: yesAdvanced Robotics Research, EarlyView.
A new mechanical model of a tendon‐actuated helical extension spring joint in surgical robots is built using Cosserat rod theory. The model can implicitly handle the unknown contacts between adjacent coils and numerically predict spring shapes from straight to significantly bent under actuation forces.
Botian Sun   +3 more
wiley   +1 more source

Hybrid Continuum Robot Designs and Architectures for Healthcare Applications

open access: yesAdvanced Robotics Research, EarlyView.
Hybrid continuum robots represent an emerging class of flexible manipulators that blend materials, structures, and actuation concepts from the established fields of soft and continuum robotics. This review introduces an accessible framework to distinguish key hybridization approaches, surveys current designs aimed at complex clinical applications, and ...
Burak Ozdemir   +4 more
wiley   +1 more source

Advanced Flexible Robotic Systems for the Early Diagnosis and Treatment of Cancer and Cardiovascular Diseases

open access: yesAdvanced Robotics Research, EarlyView.
Flexible surgical robots are advancing minimally invasive interventions for cardiovascular diseases and cancer by enabling precise navigation through complex, submillimeter anatomical pathways. This review highlights recent innovations in actuation, bio‐integrated sensing, AI‐assisted control, and friction‐reduction technologies, discusses current ...
Hermione Truong   +14 more
wiley   +1 more source

Notch [PDF]

open access: yesCurrent Biology, 2000
openaire   +2 more sources

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang   +9 more
wiley   +1 more source

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