Results 141 to 150 of about 296,712 (303)
Study on the mechanism of the Notch-mediated Akt activation
, 2010 Notch 訊息的傳遞可以調控多項生物性功能，而已知Notch可藉由活化PI3K-Akt的訊息傳遞調控細胞凋亡。但目前對於Notch如何活化PI3K-Akt訊息並不清楚。在本研究中，我們探討Notch 活化 Akt 的幾個可能途徑: ㄧ個是透過Notch本身的轉錄能力，另ㄧ個藉由先活化Lck ，第三個則經由XIAP的訊息，而造成Akt 之活化。我們先在利用Notch配體Jagged 1與DLL1 刺激DO11.10 與NIH3T3 細胞皆可造成 Akt 的活化。證實Notch 的活化確實能誘導 Akt ...
Yang, Yu-Hsuan, 楊鈺璇
core
Advanced Science, EarlyView.This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong +7 more
wiley +1 more source
Experimental and Parametric Analysis of Pull-Out Resistance of Notched T-Perfobond Connectors
Applied SciencesTo enhance the uplift capacity and facilitate the installation of multi-row perfobond connectors at shallow burial depths, this study puts forward a novel notched T-perfobond connector.
Zifa Dong +6 more
doaj +1 more source
Advanced Science, EarlyView.NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider +14 more
wiley +1 more source
Advanced Science, EarlyView.Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong +20 more
wiley +1 more source
Kit-independent mast cell adhesion mediated by Notch [PDF]
Kit/CD117 plays a crucial role in the cell–cell and cell–matrix adhesion of mammalian mast cells (MCs); however, it is unclear whether other adhesion molecule(s) perform important roles in the adhesion of MCs.
4680 +20 more
core +1 more source
Charting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing +21 more
wiley +1 more source
Chinese Journal of Lung CancerBackground and objective Lung cancer is the most common type of cancer, accounting for more than half of all cancer cases, with lung adenocarcinoma (LUAD) representing over half of lung cancer patients.
Yishan HUO +3 more
doaj +1 more source
Notch signaling regulates pulmonary fibrosis
Frontiers in Cell and Developmental BiologyPulmonary fibrosis is a progressive interstitial lung disease associated with aging. The pathogenesis of pulmonary fibrosis remains unclear, however, alveolar epithelial cell injury, myofibroblast activation, and extracellular matrix (ECM) accumulation ...
Xinyue Zhang +3 more
doaj +1 more source