Results 191 to 200 of about 110,460 (323)

Notch1 E95 in situ

open access: yes, 2015
In situ hybridization for Notch1 of a E9.5 embryo (transverse section).
Elizabeth Jones (679862)
core   +1 more source

Understanding exosomes in regenerative dentistry

open access: yesPeriodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad   +2 more
wiley   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass   +2 more
wiley   +1 more source

Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1

open access: yes, 2017
The receptor Notch1 plays an important role in malignant progression of many cancers, but its regulation is not fully understood. In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7-dependent proteasomal degradation of
전경희
core   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

Xiaoai Jiedu Recipe suppresses hepatocellular carcinogenesis through the miR‐200b-3p /Notch1 axis

open access: yesCancer Management and Research, 2020
Wenli Qiu,1 Zhongqiu Wang,1 Rong Chen,2 Haibo Shi,3 Yanxia Ma,4 Hongli Zhou,5 Muhan Li,4 Wenting Li,4 Haibin Chen,6 Hongguang Zhou7 1Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, Republic of ...
Qiu W   +9 more
doaj  

Neurodevelopmental Consequences Induced by Early‐Life Lead Exposure Through Disruption of Neurotransmitter Pathways and Molecular Mechanisms: A Systematic Review

open access: yesDevelopmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha   +3 more
wiley   +1 more source

Prognostic Impact of Tumor Stage and Growth Pattern in Sinonasal Adenoid Cystic Carcinoma: A 15‐Year Population‐Based Study

open access: yesHead &Neck, Volume 48, Issue 7, Page 1830-1840, July 2026.
ABSTRACT Background Sinonasal adenoid cystic carcinoma (AdCC) has a limited prognosis. This study assesses its incidence and prognostic factors in The Netherlands, focusing on histopathological features. Methods Adult patients diagnosed during 2008–2022 were retrieved through the Netherlands Cancer Registry and the Dutch Pathology Registry.
Lise J. van de Velde   +9 more
wiley   +1 more source

Wound Healing and Angiogenic Profiling of Dermal Endothelial Cells Isolated From People With Type 2 Diabetes

open access: yesThe FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Primary human dermal microvascular endothelial cells (HDMVECs) isolated from individuals with type 2 diabetes (T2D) exhibit dysregulated intrinsic properties, including altered morphology, reduced nitric oxide (NO) availability, and loss of endothelial identity.
James Shadiow   +14 more
wiley   +1 more source

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