Results 211 to 220 of about 110,460 (323)

T‐Cell Acute Lymphoblastic Leukemia in a Young Patient With Andersen–Tawil Syndrome Successfully and Safely Treated With Intensive Chemotherapy Including Potential Precipitating Drugs: A Case Report After 3.5 Years of Follow‐up

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Andersen–Tawil syndrome (ATS) is a rare, hereditary channelopathy characterized by periodic paralysis, cardiac arrhythmias, and sometimes developmental anomalies. No association with hematologic malignancies has previously been reported. We describe the case of a 27‐year‐old man with genetically confirmed Type 1 ATS who developed T‐cell acute ...
Ramy Rahmé, Paule Moussounda Bamba, Thi Thuy Duong Do, Anthony Behin, Estelle Gandjbakhch, Claude Gardin, Thorsten Braun   +6 more
wiley   +1 more source

Disrupting Notch signalling by a small molecule inhibiting dihydroorotate dehydrogenase activity. [PDF]

Sci Rep
Braune EB, Wienke D, Seshire A, Heinrich T, Haraldsson M, Lain S, Lendahl U.   +6 more
europepmc   +1 more source

Signaling by NOTCH1

Reactome - a curated knowledgebase of biological pathways, 2012
openaire   +1 more source

Comparative Genomic Profiling and Prognostic Impact in Recurrent and/or Metastatic Hypopharyngeal and Esophageal Squamous Cell Carcinoma

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
ABSTRACT Objective This study aimed to characterize the mutational profile of recurrent and/or metastatic esophageal squamous cell carcinoma (ESCC) and hypopharyngeal squamous cell carcinoma (HPSCC). Methods Data from 1319 consecutive patients with ESCC and 195 patients with HPSCC registered in the Center for Cancer Genomics and Advanced Therapeutics ...
Hiromi Nagano, Satoshi Kiyama, Takayuki Kyutoku, Hayato Matsumoto, Masaru Yamashita   +4 more
wiley   +1 more source

miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis. [PDF]

Int J Mol Med
Wang X, Song L, Wang J, Xie Q, Wang Y, Li C, Wang T, Du Y.   +7 more
europepmc   +1 more source

Distinct Associations of <i>GTF2I</i>, <i>TP53</i>, and <i>NOTCH1</i> Variants with Indolent and Aggressive Thymic Epithelial Tumors in Vietnamese Patients. [PDF]

Genes (Basel)
Le DM, Nguyen TX, Dang TC, Tran ND, Nguyen NL, Dang TT, Nguyen TH, Nguyen HH, Nguyen DQ, Do TT.   +9 more
europepmc   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

GAS5 mediates notch signaling to exacerbate calcium oxalate-induced renal injury through the NF-κB/NLRP3 axis by promoting macrophage polarization. [PDF]

Cell Mol Life Sci
Zhang L, Yang S, Qi Y, Zhou H, Zhang S, Xu C, Liao Q, Yao R, Qi S.   +8 more
europepmc   +1 more source

Activating NOTCH1 Mutation [PDF]

, 2020
openaire   +1 more source

Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
Environmental and lifestyle exposures reshape the cardiovascular epigenome through coordinated regulation of DNA methylation, histone modifications, noncoding RNAs, and RNA methylation (m6A). These multilayered mechanisms drive enhancer‐centered regulatory network remodeling and epigenomic plasticity in cardiovascular diseases, highlighting emerging ...
Wangzheqi Zhang, Chenyang Mu, Rui Zhao, Runwei Ma, Xuehai Liu, Haoling Zhang, Zengwu Wang, Jing‐jing Zhang   +7 more
wiley   +1 more source