Results 221 to 230 of about 110,460 (323)

LncRNA LINC01579/miR-579-3p axis promotes gastric cancer progression via NOTCH1 pathway. [PDF]

World J Surg Oncol
Geng Y, Gong S, Xue Q, You J, Cao M, Xu B, Lin Y, Sun Z, Jin C.   +8 more
europepmc   +1 more source

Inducible T Cell Costimulator Ligand and Inducible T Cell Costimulator Stratification Identify Dichotomous Tumor Microenvironment and Guide Chemo‐Immunotherapy in Small Cell Lung Cancer

MedComm, Volume 7, Issue 6, June 2026.
In small cell lung cancer, high tumor ICOSLG expression drives a microenvironment enriched with immunosuppressive T cells and M2 macrophages. Conversely, ICOSLG low tumors promote CD8+ T cell infiltration. Clinically, high ICOSLG levels predict poor response to immune checkpoint inhibitors and worse survival, whereas low ICOSLG expression indicates ...
Qiji Guo, Yan Chen, Jijun Sun, Hongyi Zhang, Shuyu Ji, Huansha Yu, Lele Zhang, Haiyang Hu, Peng Zhang, Jing Zhang   +9 more
wiley   +1 more source

Erratum: Biofunctional study on chemoresistance in esophageal squamous carcinoma cells induced by missense mutation of <i>NOTCH1 p.E450K</i>. [PDF]

J Thorac Dis
Editorial Office.
europepmc   +1 more source

Multi‐Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia

MedComm, Volume 7, Issue 6, June 2026.
Preeclampsia, a severe pregnancy‐induced disorder unique to humans, affects ∼5% of pregnancies globally. To understand the pathogenesis of preeclampsia, this study performed a comprehensive multi‐omics analysis of early pregnancy placental biopsies (chorionic villus samples) from pregnancies that later developed preterm/term preeclampsia, compared to ...
Ellen Menkhorst, Guannan Yang, Yimiao Yu, Leilani L. Santos, Wei Zhou, Argyro Syngelaki, Swati Varshney, Nicholas A. Williamson, Kaori Koga, Daniel Lorber Rolnik, Fabricio da Silva Costa, Kypros Nicolaides, Kim‐Anh Lê Cao, Evdokia Dimitriadis   +13 more
wiley   +1 more source

The endosteal niche regulates breast cancer cell dormancy in bone: identification of new molecular determinants. [PDF]

Bone Res
Maurizi A, Salbini M, Ciocca M, Rea M, Tocchini-Valentini GD, Merolle M, Taipaleenmäki H, Andreasen CM, Pellegrini M, Teti A.   +9 more
europepmc   +1 more source

Klf4 Regulates Notch1 Expression And Signaling During Epithelial Transformation

, 2006
Notch1 and KLF4 function in the specification of epithelial cell fates, and each can act as a context-dependent oncogene or tumor suppressor. We report that KLF4 directly regulates transcription of Notch1 and that cleavage of full-length Notch1 to the ...
Liu, Zhaoli
core  

Comprehensive Integrated Single‐Cell and Spatial Transcriptomics Unveil the Dynamic Landscape of Betel Nut‐Associated Oral Mucosal Carcinogenesis and Its Tumor Microenvironment

MedComm, Volume 7, Issue 6, June 2026.
ABSTRACT Betel nut chewing is a major etiological factor for oral squamous cell carcinoma (OSCC), yet its mechanistic underpinnings remain poorly defined. Here, we performed single‐cell RNA sequencing and spatial transcriptomics from six OSCC patients to comprehensively dissect the tumor microenvironment (TME) dynamics and cellular heterogeneity ...
Wei Dong, Shuojin Huang, Yijun Wu, Congyuan Cao, Jiaxue Li, Qianting He, Anxun Wang   +6 more
wiley   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Somatic mutations reveal hyperactive Notch signaling in prurigo nodularis. [PDF]

JCI Insight
Rajeh A, Shahsavari S, Cornman H, Kollhoff A, Gupta A, Szeto MD, Kambala A, Oladipo OO, Parthasarathy V, Deng J, Marani M, Shahsavari S, Yossef SM, Vaddaraju V, Adawi W, Akiska YM, Gage DM, Wheelan S, Pritchard T, Kwatra MM, Semenov YR, Gusev A, Ho WJ, Yegnasubramanian S, Kwatra SG.   +24 more
europepmc   +1 more source

NOTCH1 wt Allele [PDF]

, 2020
openaire   +1 more source