Results 231 to 240 of about 110,460 (323)

An Engineered Nano‐Bridging Strategy Remodels the Immune Microenvironment of Esophageal Squamous Cell Carcinoma via STING Pathway Activation

MedComm, Volume 7, Issue 6, June 2026.
HA1@diABZI–HMGB1 serves as a synergistic immunomodulator for dismantling the immunosuppressive microenvironment of esophageal squamous cell carcinoma (ESCC), it integrates ESCC‐targeted recognition, HMGB1‐mediated macrophage–tumor cell bridging, and diABZI‐driven STING activation.
Chaofan Huang, Xin Tang, Yixiao Zhao, Dafu Xu, Congyong Sun, Chenlong Wang, Fei Xie, Fangyi Xu, Chao Luo, Li Zhang, Qilong Wang   +10 more
wiley   +1 more source

NFIB Regulates Chemoresistance in Small Cell Lung Cancer by Suppressing Notch Signaling Activity. [PDF]

Cancer Rep (Hoboken)
Qin W, Wang Z, Deng S, Qiu H, Meng H, Geng J.   +5 more
europepmc   +1 more source

A Data‐Driven Redefinition of Early Relapse in Pediatric T Cell Acute Lymphoblastic Leukemia: Evidence for Progression of Disease 15 Months

Med Research, Volume 2, Issue 2, Page 227-235, June 2026.
Data‐driven redefinition of early relapse in pediatric T‐ALL using hazard modeling, cumulative incidence, and time‐dependent HR across 1533 patients in three independent cohorts identifies 15 months as the optimal threshold. By integrating temporal risk metrics and external validation, this study provides evidence for POD ≤ 15 months as a data‐driven ...
Na Zhang, Wenli Tang, Yali Shen, Yance Feng, Hui Shi, Binjun Xiong, Hua You   +6 more
wiley   +1 more source

Genomic alterations and dynamic molecular residual disease monitoring predict pathological response to neoadjuvant chemoimmunotherapy in esophageal squamous cell carcinoma. [PDF]

Front Immunol
Shen D, Liang J, Yan J, Lu W, Chen D, Tao K, Wang M, Chen S, Chen Q.   +8 more
europepmc   +1 more source

Notch 1 (NOTCH1) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Modeling NOTCH1 haploinsufficiency [PDF]

Nature Genetics, 2015
openaire   +1 more source

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source

Aerobic exercise significantly alters <i>Notch1</i> signaling in a neurotoxic hippocampal rat model of Alzheimer's disease. [PDF]

J Alzheimers Dis
Tavan Y, Roozegar S, Mohammadi ZF, Akbari A, Nasiri K, Memarmoghaddam M, Talebi V, Patel DI.   +7 more
europepmc   +1 more source

Notch 1 (NOTCH1) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source