Results 241 to 250 of about 110,460 (323)

Functional cooperation between the B-cell receptor and NOTCH1 in regulating metabolic reprogramming in chronic lymphocytic leukemia. [PDF]

Leukemia
Fascì A, Vallone FE, Nabelsi N, Viry E, Sana I, Morabito A, Seghezzi S, Pesce NA, Rovere M, Bertola N, Duculty C, Ravera S, Mouhssine S, Muzio M, Ghia P, Vitale C, Coscia M, Moussay E, Gaidano G, Allan J, Furman RR, Paggetti J, Vaisitti T, Deaglio S.   +23 more
europepmc   +1 more source

Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations and mRNA Transcripts. [PDF]

Cancer Discov
Yuan DJ, Zinno J, Botella T, Dhingra D, Wang S, Hawkins AG, Swett A, Sotelo J, Raviram R, Hughes C, Potenski C, Godfrey KD, Ainsworth KM, Xu S, Que J, Abrams JA, Yokoyama A, Kakiuchi N, Ogawa S, Landau DA.   +19 more
europepmc   +1 more source

NOTCH1 Gene Mutation [PDF]

, 2020
openaire   +1 more source

Molecular and Cell Biological Characterization of Patient‐Derived Head and Neck Squamous Carcinoma Cell Lines

Cancer Science, Volume 117, Issue 6, Page 1623-1634, June 2026.
Patient‐derived head and neck squamous cell carcinoma (HNSCC) cells were genomically and cytogenetically characterized, revealing actionable alterations and chromosomal instability. Targeted therapies suppressed growth according to EGFR amplification or PIK3CA mutation status.
Kazue Ito, Noriko Ishida, Shin Ito, Norihisa Shindo, Satoshi Souma, Mai Mochizuki, Haruna Fujimori, Keiichi Tamai, Takayuki Imai, Tomoko Yamazaki, Kazunori Yamaguchi, Kento Sasaki, Yuya Miyakura, Shigekazu Murakami, Yuka Unno, Naoki Asano, Yukinori Asada, Jun Yasuda   +17 more
wiley   +1 more source

Molecular variants, clonal evolution and clinical relevance in pediatric and adult T-cell lymphoblastic neoplasia. [PDF]

Blood Cancer J
Sandmann S, Te Vrugt M, Randau G, Beder T, Neumann M, Lange T, Alfert A, Mueller S, Hotfilder M, Rossi C, Eckert C, Moericke A, Horns JM, Zimmermann M, Varghese J, Brüggemann M, Burkhardt B.   +16 more
europepmc   +1 more source

CD90 Promotes Gastric Cancer Progression by Regulating SLC1A5‐Mediated Glutamine Metabolism Through YY1

Cancer Science, Volume 117, Issue 6, Page 1748-1765, June 2026.
The CD90‐YY1‐SLC1A5 axis plays a significant role in gastric cancer. CD90 promotes the binding of YY1 to the SLC1A5 promoter. CD90 regulates SLC1A5‐mediated glutamine metabolism and ferroptosis. ABSTRACT CD90 (THY1) is a cell surface glycoprotein that plays a crucial role in the occurrence and development of various malignant tumors.
Zihua Zhou, Siyi Liu, Chenyu Zhang, Jun Deng, Lin Liang, Yanhong Zhou   +5 more
wiley   +1 more source

Folic acid modulates the Notch1/NF-κB pathway in a rat model of lipopolysaccharide-activated hippocampal microglia. [PDF]

Front Neuroanat
Abd El-Kader M, Farrag EAE, El-Gamal R, El Nashar EM, Alshehri AM, Aldahhan RA, Al-Khater KM, El-Desouky S, El-Sherbeni MW, Ebrahim NA.   +9 more
europepmc   +1 more source

PAX8‐positive conventional urothelial carcinomas of the urinary bladder and their distinct molecular profiles – A clinicopathologic study of 101 consecutive cases with next‐generation sequencing in 20 cases

Histopathology, Volume 88, Issue 7, Page 1315-1323, June 2026.
PAX8 expression in urothelial carcinoma was investigated in 101 consecutive transurethral resections of the urinary bladder. PAX8 was positive in 10% of cases, with targeted molecular testing of these cases revealing universal TERT promoter mutations and frequent alterations in TSC1, NOTCH1 and WT1. Aims PAX8 immunohistochemistry (IHC) is often used to
Sarah Mae Lammert, Wendy Luo, Allen C Zhu, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Knockdown of Lymphoid Enhancer-binding Factor 1 Inhibits Pancreatic Adenocarcinoma Growth and Neoangiogenesis by Curbing Notch1 and Nuclear Factor Kappa B Signaling Pathways. [PDF]

Pancreas
Ping G, Cai G, Wei Y, Mo X, Liu L, Zhu W, Zhang Y.   +6 more
europepmc   +1 more source

Significance of Myelodysplasia‐Related Mutations and the Genetic Landscape of Acute Leukemias of Ambiguous Lineage

International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 512-520, June 2026.
ABSTRACT The recent fifth edition WHO classification and ICC classification systems have moved further toward genetically defined classifications of acute leukemias. Both now recognize myelodysplasia‐related (MR) mutations as defining of MDS‐related AML (AML‐MR).
Timothy J. Kirtek, Olga K. Weinberg
wiley   +1 more source