Results 241 to 250 of about 118,516 (288)

Mutational Landscape and Clinical Impact of SPEN Mutations in Patients with Chronic Lymphocytic Leukemia. [PDF]

Cancers (Basel)
Nirmalanantham P, Quesada AE, Ghosh A, Lin P, Ok CY, Yang RK, Fang H, Garces S, Kanagal-Shamanna R, Loghavi S, Routbort MJ, Yin CC, Wei W, Pasyar S, Bassett R, El Hussein S, Jain N, Burger J, Wierda WG, Wang S, Bueso-Ramos C, Patel KP, Medeiros LJ, Jelloul FZ.   +23 more
europepmc   +1 more source

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression. [PDF]

Adv Sci (Weinh)
Wang Z, Ye D, Wu L, Liu J, Pan B, Zhang Z, Zhang X, Yao Y, Tang N.   +8 more
europepmc   +1 more source

Unveiling the Crucial Nexus: Mitochondrial Quality Control as a Central Driver in Metabolic Dysfunction‐Associated Steatotic Liver Disease Pathogenesis

Cell Proliferation, Volume 59, Issue 2, February 2026.
Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu, Junqi Wang, Nan Lu, Zhijiang Guo, Sang‐Bing Ong, Yong Gao, Hao Zhou, Xing Chang, Miao Meng   +8 more
wiley   +1 more source

Asiatic Acid Attenuates Salmonella typhimurium-Induced Neuroinflammation and Neuronal Damage by Inhibiting the TLR2/Notch and NF-κB Pathway in Microglia. [PDF]

Int J Mol Sci
Zou W, Li J.
europepmc   +1 more source

PI3Kγ Deficiency Suppresses Cutaneous Squamous Cell Carcinoma Formation by Modulating the Tumour Microenvironment Rather Than by Directly Regulating Keratinocyte Proliferation

Experimental Dermatology, Volume 35, Issue 2, February 2026.
ABSTRACT Phosphatidylinositol‐3 kinase (PI3K) is a central regulator of cell proliferation, survival, metabolism, and migration via the downstream AKT/mTOR pathway. Although activating mutations in the catalytic subunit of PI3Kα (p110α) have been documented in various cancers, including cutaneous squamous cell carcinoma (cSCC), the role of PI3Kγ (p110γ)
Aya Toyoshima, Natsuko Noguchi, Tomoko Suzuki, Takako Kuroki, Masami Kagaya, Fumino Oda, Michihiro Kono, Junko Sasaki, Takehiko Sasaki, Hidehisa Saeki, Shin‐Ichi Osada   +10 more
wiley   +1 more source

Low SVEP1 in intrahepatic cholangiocarcinoma mediates phenotype switching-driven metastasis by Jag2/Notch1/Hes5. [PDF]

Cell Death Dis
Chen L, Han Z, Tian X, Zhu K, Gong W, Liu Y, Wang Y, Xia Y, Song P, Tang W, Kokudo N, Chen L, Luo Y, He Y, Song T, Guo H.   +15 more
europepmc   +1 more source

Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples [PDF]

, 2020
Barwe, Sonali P., Crowgey, Erin L., Druley, Todd E., Gopalakrisnapillai, Anilkumar, Kolb, E. Anders, Mahajan, Nitin   +5 more
core   +1 more source

WHO classification of skin tumours: key updates in the fifth edition

Histopathology, Volume 88, Issue 3, Page 555-568, February 2026.
This review article summarizes the key updates in the 5th edition of the WHO Classification of Skin Tumours. It provides an overview of the major changes and new entities specific to the skin section, covering areas such as epidermal, melanocytic, mesenchymal and other tumours. The 5th edition of the World Health Organization Classification of Tumours (
Gabrielle Goldman‐Lévy, Raymond Barnhill, Boris C. Bastian, Werner Kempf, David Elder, Pedram Gerami, Wayne Grayson, Dmitry Kazakov, Daniela Massi, Jane Messina, Arnaud de la Fouchardière, Alexander J. Lazar, Thomas Brenn, Brian Rous, Andrew Field, Anthony Gill, Jennelle C. Hodge, Joseph D Khoury, Katia Leite, Shahin Sayed, Puay Hoon Tan, Rosalie Elenitsas, Eduardo Calonje, Lyn M. Duncan, Liang Zhiyong, Holger Moch, Rajendra Singh, Harshima Wijesinghe, Ian Cree, Dilani Lokuhetty   +29 more
wiley   +1 more source

Characterising the Periodontal Granulation Tissue Using scRNAseq

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 308-320, February 2026.
ABSTRACT Aim To investigate the cellular composition and molecular mechanisms of periodontal granulation tissue formation using single‐cell RNA sequencing (scRNA‐seq), aiming to enhance the understanding of periodontal disease pathogenesis and identify potential targets for regenerative therapies.
Wentao Zhu, Kathy Fung, Pawan Dhami, Paul Sharpe, Jan Krivanek, Luigi Nibali, Cheng Zhang, Vitor C. M. Neves   +7 more
wiley   +1 more source