Results 251 to 260 of about 118,516 (288)

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

<i>NOTCH1</i> Mutation Is Associated With Response to Bruton Tyrosine Kinase Inhibitors in Chronic Lymphocytic Leukemia: A Retrospective Study. [PDF]

EJHaem
Haméon C, Houot R, Gyan E, Vallet N, Lachot S, Ganard M, Herault O, De Guibert S, Pastoret C, Dartigeas C.   +9 more
europepmc   +1 more source

hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is essential for oocyte development and female fertility. Oocyte‐specific deletion of Hnrnpu leads to follicular arrest, impaired meiotic maturation, mitochondrial dysfunction, and infertility.
Jinmei Li, Bei Chen, Yujiao Wen, Yanqing Wu, Kuan Liu, Jingshou Chen, Shuangqi Wang, Shenglei Feng, Juan Dong   +8 more
wiley   +1 more source

Methylation Landscapes of Cartilage in Hip Osteoarthritis. [PDF]

Genet Res (Camb)
Jiang R, Wang M, Tan G, Lv J, Jin X, Liu Y, Wu R, Shi D.   +7 more
europepmc   +1 more source

Exendin-4 Reduces Senescence of Inflammation-Induced Periodontal Ligament Stem Cells Through SIRT1/Notch1 Signaling. [PDF]

Stem Cells Int
Xu Y, Zheng J, Liu M, Fu Z, Wang P.
europepmc   +1 more source

Spatiotemporal fluorescence imaging of microRNA activity in 3-D models of human epidermis reveals contribution of the Notch pathway in the regulation of miR-30a in aging skin. [PDF]

JID Innov
Gonzalez Torres A, Chevalier FP, Aquino R, Aimard M, Baril P, Lamartine J.   +5 more
europepmc   +1 more source

Notch interaction with RUNX factors regulates initiation of the T-lineage program. [PDF]

J Exp Med
Kama Y, Hirano KI, Masuhara K, Endo Y, Suzuki Y, Fujimoto M, Matsuda T, Yahata T, Kato M, Hozumi K, Tanaka T, Hosokawa H.   +11 more
europepmc   +1 more source

A Novel Palmitoylation-Related Molecular Signature for Predicting and Therapeutically Targeting Alzheimer's Disease. [PDF]

Mol Neurobiol
Miao X, Luo K, Li Y, Zhou Y, Wei M, Zhang T, Hu Y, Wang H, Jia J.   +8 more
europepmc   +1 more source

A novel NOTCH1 nonsense variant in a bicuspid aortic valve family with intrafamilial clinical heterogeneity. [PDF]

BMC Cardiovasc Disord
Chen Q, Xu ZY, Chi W, Chen X, Zou J, Chen T, Wu MQ, Ruan DD, Yu HP, Zhang JH, Gao MZ, Zhang L, Liao LS, Fang ZT, Lin F, Luo JW, Chen L.   +16 more
europepmc   +1 more source

Immunohistochemical Evaluation of NOTCH1 Signaling Pathway in Oral Squamous Cell Carcinoma: Clinical and Prognostic Significance. [PDF]

Int J Mol Sci
de Vicente JC, Lequerica-Fernández P, Rivas HT, Blanco-Lorenzo V, López-Fernández A, Escalante-Narváez SA, Herrera I Nogués S, Rodrigo JP, Álvarez-Teijeiro S, García-Pedrero JM.   +9 more
europepmc   +1 more source