Results 61 to 70 of about 15,431 (206)

Genetic study of the NOTCH3 gene in CADASIL patients

Egyptian Journal of Medical Human Genetics, 2018
Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic, hereditary, neurological syndrome characterized by small vessel disease (SVD), stroke, vascular cognitive impairment and ...
Seyedeh Parisa Chavoshi Tarzjani, Seyed Abolhassan Shahzadeh Fazeli, Mohammad Hossein Sanati, Zahra Mirzayee   +3 more
doaj   +1 more source

CADASIL mutations impair Notch3 glycosylation by Fringe [PDF]

Human Molecular Genetics, 2005
Mutations in the NOTCH3 gene trigger adult-onset stroke and vascular dementia in patients with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). All CADASIL mutations described to date affect the epidermal growth factor-like (EGF-like) repeats located in the extracellular domain of the Notch3 receptor.
Joseph F, Arboleda-Velasquez, Raajit, Rampal, Erik, Fung, Diane C, Darland, Min, Liu, Maria C, Martinez, Christine P, Donahue, Manuel F, Navarro-Gonzalez, Peter, Libby, Patricia A, D'Amore, Masanori, Aikawa, Robert S, Haltiwanger, Kenneth S, Kosik   +12 more
openaire   +2 more sources

Cockroach‐Derived Leucokinin VIII Peptide Accelerates Diabetic Skin Wound Healing by Enhancing Keratinocyte Filopodia Formation

Advanced Science, EarlyView.
This study identifies the cockroach‐derived peptide leucokinin VIII as a potent accelerator of diabetic wound healing. By activating the FAK‐ACTG1 axis, the peptide drives keratinocyte migration and filopodia formation. Delivered via a developed PLGA‐PEG‐PLGA thermosensitive hydrogel for sustained release, this approach significantly hastens wound ...
Zhengshan Qin, Jinchuan Wu, Xiehua Xiao, Xirui Wang, Nianhui Ding, Xin Zhao, Lu Ma, Jie Li, Lunkun Ma, Cehua Ou, Ning Ma, Jianguo Feng   +11 more
wiley   +1 more source

Notch3 and Its Clinical Importance in Ovarian Cancer

Drugs and Drug Candidates
Background: Ovarian cancer (OC) is the most prevalent gynecological malignancy in women, often diagnosed at an advanced stage due to the absence of specific clinical biomarkers.
Bimal Prasad Jit, Alisha Behera, Sahar Qazi, Khushi Mittal, Subhadip Kundu, Babul Bansal, MD Ray, Ashok Sharma   +7 more
doaj   +1 more source

CD14 plays a critical role in pain and inflammation across multiple models of post‐traumatic osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine OA models that vary in severity of pathology and rate of progression, to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

A NOTCH3 pathogenic variant influences osteogenesis and can be targeted by antisense oligonucleotides in induced pluripotent stem cells.

PLoS ONE
Lateral Meningocele Syndrome (LMS), a disorder associated with NOTCH3 pathogenic variants, presents with neurological, craniofacial and skeletal abnormalities.
Ernesto Canalis, Jungeun Yu, Lauren Schilling, Paymaan Jafar-Nejad, Michele Carrer   +4 more
doaj   +1 more source

Notch3-Mediated mTOR Signaling Pathway Is Involved in High Glucose-Induced Autophagy in Bovine Kidney Epithelial Cells

Molecules, 2022
It is reported that Notch3 and mTOR signaling pathways are involved in autophagy, and both can be activated by high glucose (HG). However, the relationship between Notch3 and mTOR and how Notch3 affects mTOR to regulate HG-induced autophagy in bovine ...
Yaocheng Cui, Jing Fang, Hongrui Guo, Hengmin Cui, Junliang Deng, Shumin Yu, Liping Gou, Fengyuan Wang, Xiaoping Ma, Zhihua Ren, Yue Xie, Yi Geng, Ya Wang, Zhicai Zuo   +13 more
doaj   +1 more source

NOTCH3 Variants and Risk of Ischemic Stroke

PLoS ONE, 2013
Mutations within the NOTCH3 gene cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). CADASIL mutations appear to be restricted to the first twenty-four exons, resulting in the gain or loss of a cysteine amino acid.
Ross, Owen A., Soto-Ortolaza, Alexandra I., Heckman, Michael G., Verbeeck, Christophe, Serie, Daniel J., Rayaprolu, Sruti, Rich, Stephen S., Nalls, Michael A., Singleton, Andrew, Guerreiro, Rita, Kinsella, Emma, Wszolek, Zbigniew K., Brott, Thomas G., Brown, Robert D., Worrall, Bradford B., Meschia, James F.   +15 more
openaire   +5 more sources

Clinical and Genetic Landscape of Glioblastoma, IDH‐Wildtype With FGFR Gene Family Alterations

Cancer Science, EarlyView.
We analyzed 1076 cases of glioblastoma, IDH‐wildtype (GBM, IDH‐wt) using the C‐CAT genomic database to clarify the clinical and genetic features of FGFR alterations. FGFR::TACC fusions and FGFR1 mutations were identified in distinct subsets and were associated with unique co‐mutation patterns.
Yasuhito Kegoya, Yoshihiro Otani, Ryo Mizuta, Ryosuke Ikemachi, Mako Kamiura, Joji Ishida, Shinichi Toyooka, Daisuke Ennishi, Shuta Tomida, Shota Tanaka   +9 more
wiley   +1 more source

NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell Carcinoma. [PDF]

PLoS ONE, 2016
Recent studies have shown that Notch signaling is involved in many types of cancers, including oral squamous cell carcinomas (OSCCs). However, the role of Notch signaling in the tumor microenvironment is not yet fully understood.
Kou Kayamori, Ken-Ichi Katsube, Kei Sakamoto, Yoshio Ohyama, Hideaki Hirai, Akane Yukimori, Yae Ohata, Takumi Akashi, Masao Saitoh, Kiyoshi Harada, Hiroyuki Harada, Akira Yamaguchi   +11 more
doaj   +1 more source