Results 51 to 60 of about 336,762 (252)

Unlocking the Secrets of Cancer Stem Cells with γ-Secretase Inhibitors: A Novel Anticancer Strategy

Molecules, 2021
The dysregulation of Notch signaling is associated with a wide variety of different human cancers. Notch signaling activation mostly relies on the activity of the γ-secretase enzyme that cleaves the Notch receptors and releases the active intracellular ...
Maryam Ghanbari-Movahed, Zahra Ghanbari-Movahed, Saeideh Momtaz, Kaitlyn L. Kilpatrick, Mohammad Hosein Farzaei, Anupam Bishayee   +5 more
doaj   +1 more source

Probabilistic Modeling of Fatigue Life Prediction of Notched Specimens Combining Highly Stressed Volume and Theory of Critical Distance Approach

Metals
Notch and size effects significantly influence the fatigue performance of engineering components, which is crucial for ensuring structural integrity.
Bin Li, Peng Liu, Yuan Cheng, Xiaodi Wang, Xuechong Ren   +4 more
doaj   +1 more source

Carbon Ion Irradiation Downregulates Notch Signaling in Glioma Cell Lines, Impacting Cell Migration and Spheroid Formation

Cells, 2022
Photon-based radiotherapy upregulates Notch signaling in cancer, leading to the acquisition of the stem cell phenotype and induction of invasion/migration, which contributes to the development of resistance to therapy.
Vivek Kumar, Mohit Vashishta, Lin Kong, Jiade J. Lu, Xiaodong Wu, Bilikere S. Dwarakanath, Chandan Guha   +6 more
doaj   +1 more source

Effect of Notches on the Axial Fatigue Properties of Structural Steels [PDF]

, 1963
The effect of the stress concentration on the zero-to-tension axial fatigue strength of notched members of four structural steels has been studied. For each of the four steels a critical notch severity was found at which a transition in behavior takes
Munse, W.H., Sahgal, R.K., Stallmeyer, J.E.   +2 more
core  

Direct observation of domain wall structures in curved permalloy wires containing an antinotch [PDF]

, 2008
The formation and field response of head-to-head domain walls in curved permalloy wires, fabricated to contain a single antinotch, have been investigated using Lorentz microscopy.
B. Hillebrands, B. Leven, C. W. Sandweg, D. McGrouther, Donahue M. J., H. Schultheiss, Hubert A., J. N. Chapman, N. Wiese, S. J. Hermsdoerfer, S. McVitie, Thomas L.   +11 more
core   +2 more sources

Converting melanoma-associated fibroblasts into a tumor-suppressive phenotype by increasing intracellular Notch1 pathway activity.

PLoS ONE, 2021
Cancer-associated fibroblasts (CAFs) play a crucial role in cancer progression, drug resistance and tumor recurrence. We have recently shown that the Notch pathway determines the tumor-regulatory role of experimentally created 'CAFs'.
Hongwei Shao, Mecker Moller, Long Cai, Rochelle Prokupets, Cuixia Yang, Connor Costa, Kerstin Yu, Nga Le, Zhao-Jun Liu   +8 more
doaj   +1 more source

Effect of Notch Structure and Notch Bottom Diameter on the Tensile Load of a Certain GH4169 Notch Bolt for a Device for Longitudinal Separation of Fairing

Metals, 2022
The effect of the notch structure and bottom diameter of a GH4169 notch bolt for an explosive separation device used for longitudinal separation of the fairing, and GH4169 strength range on the tensile load was studied by combing simulations with tests ...
Xiaoliang Wang, Yunxian Cui, Tiebing Yuan, Xiaowei Wang, Zenghui Jiang   +4 more
doaj   +1 more source

Effect of Notch-Root Radius on Fatigue Damage of Notched FRP Plates.

Journal of the Society of Materials Science, Japan, 1993
Fatigue tests under plane bending and pulsating tension were carried out the notched FRP plates for a wide range of notch-root radii and stress amplitudes. An attention was focussed on the fatigue damage development near the notch root of specimens. The luminance at the limited spot near the notch root was measured successively during fatigue tests to ...
Hiizu HYAKUTAKE, Toshihiro YAMAMOTO
openaire   +2 more sources

Oridonin inhibits breast cancer growth and metastasis through blocking the Notch signaling

Saudi Pharmaceutical Journal, 2017
Background: Oridonin is a diterpenoid isolated from Rabdosia rubescens with potent anticancer activity. The aim of our study is to investigate the role of oridonin to inhibit growth and metastasis of human breast cancer cells.
Shixin Xia, Xiulan Zhang, Caihong Li, Honglian Guan   +3 more
doaj   +1 more source

Rutin Potentially Binds the Gamma Secretase Catalytic Site, Down Regulates the Notch Signaling Pathway and Reduces Sphere Formation in Colonospheres

Metabolites, 2022
Rutin, a natural flavonol, can modulate molecular signaling pathways and has considerable potential in cancer treatment. However, little is known about the effect of rutin on the notch signaling pathway (NSP) in cancer and cancer stem-like cells. In this
Atul Kumar Singh, Mohd Shuaib, Kumari Sunita Prajapati, Shashank Kumar   +3 more
doaj   +1 more source