Results 111 to 120 of about 1,406,843 (290)

Determining the role of a small GTPase, Ral, and an endocytic factor, epsin, in Drosophila Notch signaling [PDF]

, 2013
textCell-cell communication events are crucial to determine the fate of each cell during development. Notch signaling is involved in many different contexts in determining cell fate by mediating cell-cell communication.
Cho, Bomsoo
core  

Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity

, 2017
Abnormal enlargement of the alveolar spaces is a hallmark of conditions such as chronic obstructive pulmonary disease and bronchopulmonary dysplasia.
林泰元;曹伯年;魏淑?, Tsao, Po-Nien;Matsuoka, Chisa;Wei, Shu-Chen;Sato, Atsuyasu;Sato, Susumu;Hasegawa, Koichi;Chen, Hung-kuan;Ling, Thai-Yen;Mori, Munemasa;Cardoso, Wellington V.;Morimoto, Mitsuru   +1 more
core   +1 more source

Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing

Frontiers in Immunology, 2017
Macrophages are essential immune cells necessary for regulated inflammation during wound healing. Recent studies have identified that Notch plays a role in macrophage-mediated inflammation.
Andrew S. Kimball, Amrita D. Joshi, Anna E. Boniakowski, Matthew Schaller, Jooho Chung, Ronald Allen, Jennifer Bermick, William F. Carson, Peter K. Henke, Ivan Maillard, Steve L. Kunkel, Katherine A. Gallagher   +11 more
doaj   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Delta-like 4 is indispensable in thymic environment specific for T cell development. [PDF]

, 2008
The thymic microenvironment is required for T cell development in vivo. However, in vitro studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta-like (Dll)1 or Dll4, they differentiate into the T cell lineage in the ...
Holländer, Georg, Habu, S., Holländer, G. A., Hozumi, K., Hirano, K, Mailhos, C, Ken-ichi Hirano, Negishi, N, Saulius Zuklys, Habu, S, Zuklys, S, Yahata, T., Sonoko Habu, Mailhos, C., Georg A. Holländer, Naoko Negishi, Ando, K., Ando, K, Kiyoshi Ando, Holländer, GA, Shima, D. T., Negishi, N., Carolina Mailhos, Hozumi, K, Yahata, T, Shima, DT, Hirano, K., Katsuto Hozumi, Takashi Yahata, David T. Shima, Zuklys, S.   +30 more
core   +1 more source

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

Signal Transduction and Targeted Therapy
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution.
Qingmiao Shi, Chen Xue, Yifan Zeng, Xin Yuan, Qingfei Chu, Shuwen Jiang, Jinzhi Wang, Yaqi Zhang, Danhua Zhu, Lanjuan Li   +9 more
doaj   +1 more source

Non-canonical Notch signaling drives activation and differentiation of peripheral CD4+ T cells

Frontiers in Immunology, 2014
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-JΚ, resulting in the activation of downstream target genes.
Anushka eDongre, Anushka eDongre, Lalitha eSurampudi, Rebecca G Lawlor, Abdul H Fauq, Lucio eMiele, Todd E Golde, Lisa M Minter, Lisa M Minter, Barbara A Osborne, Barbara A Osborne   +10 more
doaj   +1 more source

Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity. [PDF]

Front Cell Dev Biol, 2023
Brisset M, Mehlen P, Meurette O, Hollande F.   +3 more
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.

PLoS ONE, 2011
Notch signaling requires ligand internalization by the signal sending cells. Two endocytic proteins, epsin and auxilin, are essential for ligand internalization and signaling. Epsin promotes clathrin-coated vesicle formation, and auxilin uncoats clathrin
Susan M L Banks, Bomsoo Cho, Suk Ho Eun, Ji-Hoon Lee, Sarah L Windler, Xuanhua Xie, David Bilder, Janice A Fischer   +7 more
doaj   +1 more source