Results 181 to 190 of about 103,072 (297)

The structural and functional significance of lipid-binding properties of human Notch ligands

The Notch receptor and its canonical ligands Jagged/Serrate and Delta-like form part of a core metazoan juxtacrine signal transduction pathway crucial for development and tissue homeostasis.
Feng, Xinyi
core   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Targeting the Notch receptor dimerization domain to inhibit Notch signalling-A new avenue of therapeutics. [PDF]

FEBS J
Hoyne GF.
europepmc   +1 more source

KSHV and the Role of Notch Receptor Dysregulation in Disease Progression. [PDF]

Pathogens, 2017
DeCotiis JL, Lukac DM.
europepmc   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Dimerization-dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors. [PDF]

FEBS J
Liu X, Wang H, Mishra G, Wu LT, Li C, van Dinther M, Liu J, Gonçalves MAFV, Ten Dijke P, Baker DA.   +9 more
europepmc   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Niche-associated Type IV collagen promotes GLP-1/Notch receptor activation in the C. elegans germline. [PDF]

Nat Commun
Martel PO, Janse van Vuuren R, Degrémont J, Turmel-Couture S, Chaudhari AM, Dologuele E, Beaulieu L, Clouet A, Narbonne P.   +8 more
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking. [PDF]

Elife, 2018
Li B, Wong C, Gao SM, Zhang R, Sun R, Li Y, Song Y.   +6 more
europepmc   +1 more source